Update on Antiphospholipid Syndrome: Ten Topics in 2017

Update on Antiphospholipid Syndrome: Ten Topics in 2017 Purpose of Review This review focuses on new clinical aspects of antiphospholipid syndrome (APS) in the last 5 years. Recent Findings The pathogenesis of APS is related to endothelial activation by mechanisms other than autoantibody-mediated massive coagulation. These include Toll-like receptors, the m-TORC pathway, and neutrophil activation, inducing an uncon- trolled inflammatory cascade. Given these new pathogenetic hypotheses, the treatment of APS could be directed towards a fine balance between anticoagulation and immunomodulation. A hot topic is how to consider asymptomatic antiphospholipid (aPL) carriers, with or without systemic lupus erythematosus (SLE), during pregnancy, or during their life in general: to treat or not to treat? New findings on long-standing APS, regarding survival, comorbidities, and evolution in other autoimmune conditions, have become available, including new insights into aPL as potential risk factors for damage accrual in SLE and potential implications on neuropsychological involvement of children exposed to maternal aPL in utero. Summary This review summarizes recent findings on the management, treatment, and prevention of patients affected by APS or with aPL. . . . . . Keywords Anti-phospholipid antibodies Thrombosis’ pathogenesis Asymptomatic carrier APS treatment Obstetric APS Neuropsychological development Introduction New Insights into the Pathogenesis of aPL-Mediated Thrombosis and Pregnancy http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Rheumatology Reports Springer Journals

Update on Antiphospholipid Syndrome: Ten Topics in 2017

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Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Medicine & Public Health; Rheumatology
ISSN
1523-3774
eISSN
1534-6307
D.O.I.
10.1007/s11926-018-0718-4
Publisher site
See Article on Publisher Site

Abstract

Purpose of Review This review focuses on new clinical aspects of antiphospholipid syndrome (APS) in the last 5 years. Recent Findings The pathogenesis of APS is related to endothelial activation by mechanisms other than autoantibody-mediated massive coagulation. These include Toll-like receptors, the m-TORC pathway, and neutrophil activation, inducing an uncon- trolled inflammatory cascade. Given these new pathogenetic hypotheses, the treatment of APS could be directed towards a fine balance between anticoagulation and immunomodulation. A hot topic is how to consider asymptomatic antiphospholipid (aPL) carriers, with or without systemic lupus erythematosus (SLE), during pregnancy, or during their life in general: to treat or not to treat? New findings on long-standing APS, regarding survival, comorbidities, and evolution in other autoimmune conditions, have become available, including new insights into aPL as potential risk factors for damage accrual in SLE and potential implications on neuropsychological involvement of children exposed to maternal aPL in utero. Summary This review summarizes recent findings on the management, treatment, and prevention of patients affected by APS or with aPL. . . . . . Keywords Anti-phospholipid antibodies Thrombosis’ pathogenesis Asymptomatic carrier APS treatment Obstetric APS Neuropsychological development Introduction New Insights into the Pathogenesis of aPL-Mediated Thrombosis and Pregnancy

Journal

Current Rheumatology ReportsSpringer Journals

Published: Mar 15, 2018

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