Unusual Merkel cell carcinoma in a renal transplant recipient: case report and review of the literature

Unusual Merkel cell carcinoma in a renal transplant recipient: case report and review of the... Merkel cell carcinoma (MCC) is an uncommon and aggressive neuroendocrine primary skin cancer known for its high propensity for local recurrence and distant metastases. There is no consensus regarding the optimal therapeutic approach, and the relative roles of surgery, radiotherapy and chemotherapy are still controversial. MCC generally affects elderly patients in areas of actinically damaged skin. Several studies suggest that a more aggressive course is observed in immunocompromised patients such as organ transplant recipients. Clinically, MCC usually appears as a rapidly growing, dome-shaped and solitary nodule. More than half of these tumours occur in the head and neck, and can become a challenge for the plastic and reconstructive surgeon. An unusual case of this cutaneous malignancy is presented in a renal transplant recipient. The tumour was located in the medial canthus of the eye. Tumour resection was performed and a reverse flow pre-auricular island flap and a forehead flap were used for reconstruction. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Plastic Surgery Springer Journals

Unusual Merkel cell carcinoma in a renal transplant recipient: case report and review of the literature

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Publisher
Springer-Verlag
Copyright
Copyright © 2005 by Springer-Verlag
Subject
Medicine
ISSN
0930-343X
eISSN
1435-0130
D.O.I.
10.1007/s00238-005-0805-4
Publisher site
See Article on Publisher Site

Abstract

Merkel cell carcinoma (MCC) is an uncommon and aggressive neuroendocrine primary skin cancer known for its high propensity for local recurrence and distant metastases. There is no consensus regarding the optimal therapeutic approach, and the relative roles of surgery, radiotherapy and chemotherapy are still controversial. MCC generally affects elderly patients in areas of actinically damaged skin. Several studies suggest that a more aggressive course is observed in immunocompromised patients such as organ transplant recipients. Clinically, MCC usually appears as a rapidly growing, dome-shaped and solitary nodule. More than half of these tumours occur in the head and neck, and can become a challenge for the plastic and reconstructive surgeon. An unusual case of this cutaneous malignancy is presented in a renal transplant recipient. The tumour was located in the medial canthus of the eye. Tumour resection was performed and a reverse flow pre-auricular island flap and a forehead flap were used for reconstruction.

Journal

European Journal of Plastic SurgerySpringer Journals

Published: Jan 1, 2006

References

  • Merkel cell carcinoma: a rare cause of hypervascular nasal tumor
    Azizi, L; Marsot-Dupuch, K; Bigel, P; Mzali, S; Meyer, B; Tubiana, M
  • Early aggressive treatment for Merkel cell carcinoma improves outcome
    Kokoska, ER; Kokoska, MS; Collins, BT
  • Multimodality treatment of Merkel cell carcinoma: case series and review of 1024 cases
    Medina-Franco, H; Urist, MM; Fiveash, J; Heslin, MJ; Bland, KI; Beenken, SW
  • Trabecular carcinoma of the skin
    Toker, C

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