Unique characteristics of bat rabies viruses in big brown bats ( Eptesicus fuscus )

Unique characteristics of bat rabies viruses in big brown bats ( Eptesicus fuscus ) Rabies virus infection has been documented in several North American bat species, including Eptesicus fuscus . The virus-host relationship between bats and rabies virus (RV) is not well understood. The incidence of non-lethal RV exposure, based on the presence of viral neutralizing antibodies, demonstrates that exposure to RV does not always lead to clinical infection in bats. It is unknown how the route of exposure, rabies virus variant, or health of the bat affects the outcome following exposure. This paper describes the pathogenesis of two big brown bat RV variants in homologous host species. Our study demonstrates that RV variants obtained from the same species of bat from similar geographical areas may result in a diverse clinical progression of disease. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Unique characteristics of bat rabies viruses in big brown bats ( Eptesicus fuscus )

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Publisher
Springer Vienna
Copyright
Copyright © 2013 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-012-1551-0
Publisher site
See Article on Publisher Site

Abstract

Rabies virus infection has been documented in several North American bat species, including Eptesicus fuscus . The virus-host relationship between bats and rabies virus (RV) is not well understood. The incidence of non-lethal RV exposure, based on the presence of viral neutralizing antibodies, demonstrates that exposure to RV does not always lead to clinical infection in bats. It is unknown how the route of exposure, rabies virus variant, or health of the bat affects the outcome following exposure. This paper describes the pathogenesis of two big brown bat RV variants in homologous host species. Our study demonstrates that RV variants obtained from the same species of bat from similar geographical areas may result in a diverse clinical progression of disease.

Journal

Archives of VirologySpringer Journals

Published: Apr 1, 2013

References

  • A tale of two genomes: contrasting patterns of phylogeographic structure in a widely distributed bat
    Turmelle, AS; Kunz, TH; Sorenson, MD
  • A need for standardized rabies-virus diagnostic procedures: effect of cover-glass mountant on the reliability of antigen detection by the fluorescent antibody test
    Rudd, RJ; Smith, JS; Yager, PA; Orciari, LA; Trimarchi, CV

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