Unexpected mutations were expected and unrelated to CRISPR-Cas9 activity

Unexpected mutations were expected and unrelated to CRISPR-Cas9 activity Transgenic Res https://doi.org/10.1007/s11248-018-0081-2 LETTER TO THE EDITOR Unexpected mutations were expected and unrelated to CRISPR-Cas9 activity Lluis Montoliu C. Bruce A. Whitelaw Received: 6 April 2018 / Accepted: 26 May 2018 Springer International Publishing AG, part of Springer Nature 2018 Abstract The scientific journal Nature Methods spontaneous mutations and genetic drift. Therefore, have just retracted a publication that reported numer- the reported mutations were most likely not related to ous unexpected mutations after a CRISPR-Cas9 CRISPR-Cas9 activity. experiment based on collecting whole genome sequencing information from one control and two Keywords Off target mutations  CRISPR  Cas9 experimental genome edited mice. In the intervening Safety  Genome editing applications  Safety  Gene 10 months since publication the data presented have therapy been strongly contested and criticized by the scientific and biotech communities, through publications, open science channels and social networks. The criticism On 30th May 2017, the scientific journal Nature focused on the animal used as control, which was Methods released a publication with a striking title: derived from the same mouse strain as the experimen- unexpected mutations after a CRISPR-Cas9 editing tal individuals but from an unrelated sub-colony, in vivo (Schaefer et al. 2017a). The study http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Transgenic Research Springer Journals

Unexpected mutations were expected and unrelated to CRISPR-Cas9 activity

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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Life Sciences; Animal Genetics and Genomics; Plant Genetics and Genomics; Transgenics; Biomedical Engineering/Biotechnology; Genetic Engineering; Molecular Medicine
ISSN
0962-8819
eISSN
1573-9368
D.O.I.
10.1007/s11248-018-0081-2
Publisher site
See Article on Publisher Site

Abstract

Transgenic Res https://doi.org/10.1007/s11248-018-0081-2 LETTER TO THE EDITOR Unexpected mutations were expected and unrelated to CRISPR-Cas9 activity Lluis Montoliu C. Bruce A. Whitelaw Received: 6 April 2018 / Accepted: 26 May 2018 Springer International Publishing AG, part of Springer Nature 2018 Abstract The scientific journal Nature Methods spontaneous mutations and genetic drift. Therefore, have just retracted a publication that reported numer- the reported mutations were most likely not related to ous unexpected mutations after a CRISPR-Cas9 CRISPR-Cas9 activity. experiment based on collecting whole genome sequencing information from one control and two Keywords Off target mutations  CRISPR  Cas9 experimental genome edited mice. In the intervening Safety  Genome editing applications  Safety  Gene 10 months since publication the data presented have therapy been strongly contested and criticized by the scientific and biotech communities, through publications, open science channels and social networks. The criticism On 30th May 2017, the scientific journal Nature focused on the animal used as control, which was Methods released a publication with a striking title: derived from the same mouse strain as the experimen- unexpected mutations after a CRISPR-Cas9 editing tal individuals but from an unrelated sub-colony, in vivo (Schaefer et al. 2017a). The study

Journal

Transgenic ResearchSpringer Journals

Published: May 31, 2018

References

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