Understanding the biogenesis of polytopic integral membrane proteins

Understanding the biogenesis of polytopic integral membrane proteins J. Membrane Biol. 192, 149-157 (2003) The Journal of DOI: Membrane Biology 9 Springer-Verlag New York Inc. 2003 Topical Review R.J. Turner Membrane Biology Section, Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, 10 Center Drive MSC 1190, Bethesda MD 20892, USA Received: 17 September 2002 Introduction detail and it is this process that concerns us here. The folding of [3-barrel membrane proteins, which have Experiments carried out over the past decade have only been found in mitochondria, chloroplasts and dramatically advanced our understanding of the the outer membranes of gram-negative bacteria, is biogenesis of integral membrane proteins. It is now less well characterized (Buchanan, 1999) and will not clear that the membrane integration and assembly of be discussed. most of these proteins occurs with the assistance of a In what follows I begin with a simplified de- large complex of translocation/insertion machinery. scription of the way in which membrane proteins of An appreciation of how integral membrane proteins the a-helical bundle type are integrated into the lipid are recognized and processed by this machinery bilayer. I then return to the various steps in this provides considerable insight into their http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

Understanding the biogenesis of polytopic integral membrane proteins

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Publisher
Springer-Verlag
Copyright
Copyright © 2003 by Springer-Verlag
Subject
Life Sciences; Biochemistry, general; Human Physiology
ISSN
0022-2631
eISSN
1432-1424
D.O.I.
10.1007/s00232-002-1071-z
Publisher site
See Article on Publisher Site

Abstract

J. Membrane Biol. 192, 149-157 (2003) The Journal of DOI: Membrane Biology 9 Springer-Verlag New York Inc. 2003 Topical Review R.J. Turner Membrane Biology Section, Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, 10 Center Drive MSC 1190, Bethesda MD 20892, USA Received: 17 September 2002 Introduction detail and it is this process that concerns us here. The folding of [3-barrel membrane proteins, which have Experiments carried out over the past decade have only been found in mitochondria, chloroplasts and dramatically advanced our understanding of the the outer membranes of gram-negative bacteria, is biogenesis of integral membrane proteins. It is now less well characterized (Buchanan, 1999) and will not clear that the membrane integration and assembly of be discussed. most of these proteins occurs with the assistance of a In what follows I begin with a simplified de- large complex of translocation/insertion machinery. scription of the way in which membrane proteins of An appreciation of how integral membrane proteins the a-helical bundle type are integrated into the lipid are recognized and processed by this machinery bilayer. I then return to the various steps in this provides considerable insight into their

Journal

The Journal of Membrane BiologySpringer Journals

Published: Mar 25, 2002

References

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