Keywords Multicomponent reaction Dipyrimido[1,2-a:4,5-d]pyrimidine derivatives 2-Aminopyrimidine Cyclization Electronic supplementary material The online version of this article (doi:10.1007/s11164-017-2868- 9) contains supplementary material, which is available to authorized users. & Prashant V. Anbhule email@example.com Department of Agrochemicals and Pest Management, Shivaji University, Kolhapur, India Medicinal Chemistry Research Lab, Department of Chemistry, Shivaji University, Kolhapur, MS 416004, India 123 4104 P. T. Patil et al. Introduction In recent years, pyrimidopyrimidine moieties have attracted considerable attention in medicinal chemistry due to their signiﬁcant biological activities. The pyrim- ido[4,5-d]pyrimidines are an important group of uracils structurally related to pteridine and purines [1, 2]. Pyrimido[4,5-d]pyrimidines (Fig. 1) possesses various pharmacological activities including antitumor , anti-allergic [4, 5], anti-oxidant , anti-inﬂammatory , antibacterial , hepatoprotective , antihypertensive  and antiviral . In addition, they have also effective inhibitory properties like tyrosine kinase receptor , 5-phosphoribosyl-1-pyrophosphate synthetase  and dihydrofolate reductase . Dipyridamole VI (Fig. 1) containing pyrimidopyrimidine in its core structure is useful to inhibit lower pulmonary hypertension and phosphodiesterase enzyme, and is also used in electrocardiograms and echocardiography . Nowadays, numerous methodologies have been reported for the synthesis of pyrimido[4,5-d]pyrimidine derivatives by using three-component condensation of aryl aldehydes, amino sources (aminouracils, anilines,
Research on Chemical Intermediates – Springer Journals
Published: Jan 27, 2017
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