Uncatalyzed synthesis of new substituted dihydro-2H-dipyrimido[1,2-a,4,5-d]pyrimidine-2,4(3H)-dione

Uncatalyzed synthesis of new substituted dihydro-2H-dipyrimido[1,2-a,4,5-d]pyrimidine-2,4(3H)-dione Keywords Multicomponent reaction  Dipyrimido[1,2-a:4,5-d]pyrimidine derivatives  2-Aminopyrimidine  Cyclization Electronic supplementary material The online version of this article (doi:10.1007/s11164-017-2868- 9) contains supplementary material, which is available to authorized users. & Prashant V. Anbhule pvanbhule@gmail.com Department of Agrochemicals and Pest Management, Shivaji University, Kolhapur, India Medicinal Chemistry Research Lab, Department of Chemistry, Shivaji University, Kolhapur, MS 416004, India 123 4104 P. T. Patil et al. Introduction In recent years, pyrimidopyrimidine moieties have attracted considerable attention in medicinal chemistry due to their significant biological activities. The pyrim- ido[4,5-d]pyrimidines are an important group of uracils structurally related to pteridine and purines [1, 2]. Pyrimido[4,5-d]pyrimidines (Fig. 1) possesses various pharmacological activities including antitumor [3], anti-allergic [4, 5], anti-oxidant [6], anti-inflammatory [7], antibacterial [8], hepatoprotective [9], antihypertensive [10] and antiviral [11]. In addition, they have also effective inhibitory properties like tyrosine kinase receptor [12], 5-phosphoribosyl-1-pyrophosphate synthetase [13] and dihydrofolate reductase [14]. Dipyridamole VI (Fig. 1) containing pyrimidopyrimidine in its core structure is useful to inhibit lower pulmonary hypertension and phosphodiesterase enzyme, and is also used in electrocardiograms and echocardiography [15]. Nowadays, numerous methodologies have been reported for the synthesis of pyrimido[4,5-d]pyrimidine derivatives by using three-component condensation of aryl aldehydes, amino sources (aminouracils, anilines, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Uncatalyzed synthesis of new substituted dihydro-2H-dipyrimido[1,2-a,4,5-d]pyrimidine-2,4(3H)-dione

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Publisher
Springer Netherlands
Copyright
Copyright © 2017 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-017-2868-9
Publisher site
See Article on Publisher Site

Abstract

Keywords Multicomponent reaction  Dipyrimido[1,2-a:4,5-d]pyrimidine derivatives  2-Aminopyrimidine  Cyclization Electronic supplementary material The online version of this article (doi:10.1007/s11164-017-2868- 9) contains supplementary material, which is available to authorized users. & Prashant V. Anbhule pvanbhule@gmail.com Department of Agrochemicals and Pest Management, Shivaji University, Kolhapur, India Medicinal Chemistry Research Lab, Department of Chemistry, Shivaji University, Kolhapur, MS 416004, India 123 4104 P. T. Patil et al. Introduction In recent years, pyrimidopyrimidine moieties have attracted considerable attention in medicinal chemistry due to their significant biological activities. The pyrim- ido[4,5-d]pyrimidines are an important group of uracils structurally related to pteridine and purines [1, 2]. Pyrimido[4,5-d]pyrimidines (Fig. 1) possesses various pharmacological activities including antitumor [3], anti-allergic [4, 5], anti-oxidant [6], anti-inflammatory [7], antibacterial [8], hepatoprotective [9], antihypertensive [10] and antiviral [11]. In addition, they have also effective inhibitory properties like tyrosine kinase receptor [12], 5-phosphoribosyl-1-pyrophosphate synthetase [13] and dihydrofolate reductase [14]. Dipyridamole VI (Fig. 1) containing pyrimidopyrimidine in its core structure is useful to inhibit lower pulmonary hypertension and phosphodiesterase enzyme, and is also used in electrocardiograms and echocardiography [15]. Nowadays, numerous methodologies have been reported for the synthesis of pyrimido[4,5-d]pyrimidine derivatives by using three-component condensation of aryl aldehydes, amino sources (aminouracils, anilines,

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Jan 27, 2017

References

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