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Uncatalyzed synthesis of 3-amino-1,5-dihydro-2H-pyrrol-2-ones 2073
- Publisher
- Springer Journals
- Copyright
- Copyright © 2013 by Springer Science+Business Media Dordrecht
- Subject
- Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
- ISSN
- 0922-6168
- eISSN
- 1568-5675
- DOI
- 10.1007/s11164-013-1102-7
- Publisher site
- See Article on Publisher Site
Abstract
Uncatalyzed one-pot pseudo-four-component reaction of ethyl pyruvate, anilines, and aldehydes in n-hexane as solvent, under reflux, affords a variety of 3-amino-1,5-dihydro-2H-pyrrol-2-ones in high yield. n-Hexane is an excellent driving force in preparation of the desired products. These compounds have biological and pharmacological properties and are also used in medicinal chemistry. Use of a non-toxic and inexpensive solvent, simple and efficient synthesis, clean work-up, and high yields of the products are the advantages of this method. We report the first catalyst-free method for synthesis this class of compounds.
Journal
Research on Chemical Intermediates – Springer Journals
Published: Feb 17, 2013