Ultrasound-mediated synthesis of phenothiazine derivatives and their in vitro antibacterial and antioxidant studies

Ultrasound-mediated synthesis of phenothiazine derivatives and their in vitro antibacterial and... A series of N′-((10-alkyl-10H-phenothiazin-3-yl)methylene)benzohydrazide have been synthesized via condensation of 10-alkyl-10H-phenothiazine-3-carbaldehyde with different heterocyclic acetohydrazides. The reactions were carried out under both conventional and ultrasonic irradiation conditions. In general, improvement in rates and yields were observed when reactions were carried out under sonication compared to classical synthetic conditions. Structures of all the newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR, and mass spectra. Antibacterial activities of the synthesized compounds were studied against bacterial strains Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus cereus, and Klebsiella pneumonia. The free radical scavenging activities of synthesized compounds were screened for in vitro antioxidant activity. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Ultrasound-mediated synthesis of phenothiazine derivatives and their in vitro antibacterial and antioxidant studies

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Publisher
Springer Netherlands
Copyright
Copyright © 2013 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-013-1213-1
Publisher site
See Article on Publisher Site

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