Ultrasound-assisted facile and selective synthesis of azeto[2,1-d][1,5]benzothiazepines under solvent-free conditions and their biological activity

Ultrasound-assisted facile and selective synthesis of azeto[2,1-d][1,5]benzothiazepines under... A facile, efficient and environmentally friendly heteroannulation protocol for the exclusive synthesis of medicinally important azeto[2,1-d][1,5]benzothiazepines 3 has been developed in the presence of 10 mol% K2CO3 under sonication. In comparison to conventional synthesis, where mixture of products such as 3, phenyl-N-acetyl-2-styrylbenzothiazole 4 and 1,3-oxazine derivative 5 were formed in several hours of heating, the present method provides several advantages including selective synthesis of 3 with simpler work-up procedure, higher yields in shorter reaction time and green aspects through the avoidance of toxic catalysts and solvents. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Ultrasound-assisted facile and selective synthesis of azeto[2,1-d][1,5]benzothiazepines under solvent-free conditions and their biological activity

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Publisher
Springer Netherlands
Copyright
Copyright © 2013 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-013-1292-z
Publisher site
See Article on Publisher Site

Abstract

A facile, efficient and environmentally friendly heteroannulation protocol for the exclusive synthesis of medicinally important azeto[2,1-d][1,5]benzothiazepines 3 has been developed in the presence of 10 mol% K2CO3 under sonication. In comparison to conventional synthesis, where mixture of products such as 3, phenyl-N-acetyl-2-styrylbenzothiazole 4 and 1,3-oxazine derivative 5 were formed in several hours of heating, the present method provides several advantages including selective synthesis of 3 with simpler work-up procedure, higher yields in shorter reaction time and green aspects through the avoidance of toxic catalysts and solvents.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Jun 8, 2013

References

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