A facile, efficient and environmentally friendly heteroannulation protocol for the exclusive synthesis of medicinally important azeto[2,1-d][1,5]benzothiazepines 3 has been developed in the presence of 10 mol% K2CO3 under sonication. In comparison to conventional synthesis, where mixture of products such as 3, phenyl-N-acetyl-2-styrylbenzothiazole 4 and 1,3-oxazine derivative 5 were formed in several hours of heating, the present method provides several advantages including selective synthesis of 3 with simpler work-up procedure, higher yields in shorter reaction time and green aspects through the avoidance of toxic catalysts and solvents.
Research on Chemical Intermediates – Springer Journals
Published: Jun 8, 2013
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