J Clin Immunol (2017) 37:592–602 DOI 10.1007/s10875-017-0415-5 ORIGINAL ARTICLE Two Sides of the Same Coin: Pediatric-Onset and Adult-Onset Common Variable Immune Deficiency 1 1 2 Lauren A. Sanchez & Solrun Melkorka Maggadottir & Matthew S. Pantell & 3 4 1 Patricia Lugar & Charlotte Cunningham Rundles & Kathleen E. Sullivan & the USIDNET Consortium Received: 9 September 2016 /Accepted: 21 June 2017 /Published online: 28 July 2017 Springer Science+Business Media, LLC 2017 Abstract analysis of 457 children and adults with CVID, stratified by Purpose Common variable immunodeficiency (CVID) is a age at diagnosis. Chi-squared testing was used to compare complex, heterogeneous immunodeficiency characterized by pediatric versus adult groups. hypogammaglobulinemia, recurrent infections, and poor anti- Results After correcting for multiple comparisons, we body response to vaccination. While antibiotics and immuno- identified few statistically significant differences globulin prophylaxis have significantly reduced infectious (p ≤ 0.0004) between pediatric and adult groups. complications, non-infectious complications of autoimmunity, Pediatric-onset CVID patients had more frequent diagnoses inflammatory lung disease, enteropathy, and malignancy re- of otitis media, developmental delay, and failure to thrive main of great concern. Previous studies have suggested that compared with adult-onset CVID patients. Adult CVID CVID patients diagnosed in childhood are more
Journal of Clinical Immunology – Springer Journals
Published: Jul 28, 2017
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