Two genetic changes in cis-regulatory elements caused evolution of petal spot position in Clarkia

Two genetic changes in cis-regulatory elements caused evolution of petal spot position in Clarkia A major premise in evolutionary developmental biology is that regulatory changes, often involving cis-regulatory elements, are responsible for much morphological evolution. This premise is supported by recent investigations of animal development, but information is just beginning to accumulate regarding whether it also applies to the evolution of plant morphology 1–4 . Here, we identify the genetic differences between species in the genus Clarkia that are responsible for evolutionary change in an ecologically important element of floral colour patterns: spot position. The evolutionary shift in spot position was due to two simple genetic changes that resulted in the appearance of a transcription factor binding site mutation in the R2R3 Myb gene that changes spot formation. These genetic changes caused R2R3 Myb to be activated by a different transcription factor that is expressed in a different position in the petal. These results suggest that the regulatory rewiring paradigm is as applicable to plants as it is to animals, and support the hypothesis that cis-regulatory changes may often play a role in plant morphological evolution. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Plants Springer Journals

Two genetic changes in cis-regulatory elements caused evolution of petal spot position in Clarkia

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Publisher
Nature Publishing Group UK
Copyright
Copyright © 2017 by © The Authors 2017, under exclusive licence to Macmillan Publishers Limited, part of Springer Nature
Subject
Life Sciences; Life Sciences, general; Plant Sciences
eISSN
2055-0278
D.O.I.
10.1038/s41477-017-0085-6
Publisher site
See Article on Publisher Site

Abstract

A major premise in evolutionary developmental biology is that regulatory changes, often involving cis-regulatory elements, are responsible for much morphological evolution. This premise is supported by recent investigations of animal development, but information is just beginning to accumulate regarding whether it also applies to the evolution of plant morphology 1–4 . Here, we identify the genetic differences between species in the genus Clarkia that are responsible for evolutionary change in an ecologically important element of floral colour patterns: spot position. The evolutionary shift in spot position was due to two simple genetic changes that resulted in the appearance of a transcription factor binding site mutation in the R2R3 Myb gene that changes spot formation. These genetic changes caused R2R3 Myb to be activated by a different transcription factor that is expressed in a different position in the petal. These results suggest that the regulatory rewiring paradigm is as applicable to plants as it is to animals, and support the hypothesis that cis-regulatory changes may often play a role in plant morphological evolution.

Journal

Nature PlantsSpringer Journals

Published: Jan 3, 2018

References

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