www.nature.com/bjc ARTICLE Molecular Diagnostics Tumour buds determine prognosis in resected pancreatic ductal adenocarcinoma 1,2 3 4 3 3 3 1 3 Philipp Lohneis , Marianne Sinn , Fritz Klein , Sven Bischoff , Jana K. Strieﬂer , Lilianna Wislocka , Bruno V. Sinn , Uwe Pelzer , 5 3 1 1 3 Helmut Oettle , Hanno Riess , Carsten Denkert , Hendrik Bläker and Anja Jühling BACKGROUND: The prognostic effect of tumour budding was retrospectively analysed in a cohort of 173 patients with resected pancreatic ductal adenocarcinomas (PDACs) of the prospective clinical multicentre CONKO-001 trial. METHODS: Haematoxylin and eosin (H&E)-stained whole tissue slides were evaluated. In two independent approaches, the mean number of tumour buds was analysed according to the consensus criteria in colorectal cancer, in one 0.785 mm ﬁeld of view and additionally in 10 high-power ﬁelds (HPF) (HPF = 0.238 mm ). RESULTS: Tumour budding was signiﬁcantly associated with a higher tumour grade (p < 0.001) but not with distant or lymph node metastasis. Regardless of the quantiﬁcation approach, an increased number of tumour buds was signiﬁcantly associated with reduced disease-free survival (DFS) and overall survival (OS) (10 HPF approach DFS: HR = 1.056 (95% CI 1.022–1.092),
British Journal of Cancer – Springer Journals
Published: May 14, 2018
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