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References (44)
-
Valérie Arnoux, C. Côme, D. Kusewitt, L. Hudson, P. Savagner (2005)
Cutaneous Wound Reepithelialization -
Daoning Liu, Ang Lv, Zhi-hua Tian, Xiu-Yun Tian, Xiao-ya Guan, B. Dong, Min Zhao, C. Hao (2016)
Superior mesenteric artery margin in pancreaticoduodenectomy for pancreatic adenocarcinomaOncotarget, 8
-
Jason McMullan, Christopher Droege, Col. Strilka, Kimberly Hart, C. Lindsell (2014)
Randomized Controlled TrialEncyclopedia of Behavioral Medicine
-
(2016)
Tumor budding: the name is EMT. Partial EMT.J. Clin. Med, 5
-
B. Mitrović, D. Schaeffer, R. Riddell, R. Kirsch (2012)
Tumor budding in colorectal carcinoma: time to take noticeModern Pathology, 25
-
H. Oettle, P. Neuhaus, A. Hochhaus, J. Hartmann, K. Gellert, K. Ridwelski, M. Niedergethmann, C. Zülke, J. Fahlke, M. Arning, M. Sinn, A. Hinke, H. Riess (2013)
Adjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer: the CONKO-001 randomized trial.JAMA, 310 14
-
I. Zlobec, A. Lugli (2010)
Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: Tumor budding as oncotargetOncotarget, 1
-
Alexandru Grigore, Mohit Jolly, D. Jia, M. Farach-Carson, H. Levine, Alexandru Dan, Edu, F.-C, H. Edu (1997)
Clinical Medicine -
Kouji Tanaka, Tadanobu Shimura, Takahito Kitajima, S. Kondo, Shozo Ide, Y. Okugawa, S. Saigusa, Y. Toiyama, Y. Inoue, T. Araki, K. Uchida, Y. Mohri, M. Kusunoki (2014)
Tropomyosin-related receptor kinase B at the invasive front and tumour cell dedifferentiation in gastric cancerBritish Journal of Cancer, 110
-
A. Lugli, E. Karamitopoulou, Inti Zlobec (2012)
Tumour budding: a promising parameter in colorectal cancerBritish Journal of Cancer, 106
-
T. Eberlein (2008)
Adjuvant Chemotherapy With Gemcitabine vs Observation in Patients Undergoing Curative-Intent Resection of Pancreatic Cancer: A Randomized Controlled TrialYearbook of Surgery, 2008
-
Vishal Das, Sourya Bhattacharya, C. Chikkaputtaiah, Saugata Hazra, Mintu Pal (2019)
The basics of epithelial–mesenchymal transition (EMT): A study from a structure, dynamics, and functional perspectiveJournal of Cellular Physiology, 234
-
Kate O'Connor, H. Li-Chang, S. Kalloger, R. Peixoto, D. Webber, D. Owen, D. Driman, R. Kirsch, S. Serra, C. Scudamore, D. Renouf, D. Schaeffer (2015)
Tumor Budding Is an Independent Adverse Prognostic Factor in Pancreatic Ductal AdenocarcinomaThe American Journal of Surgical Pathology, 39
-
M. Koike, Y. Kodera, Y. Itoh, G. Nakayama, M. Fujiwara, N. Hamajima, A. Nakao (2008)
Multivariate Analysis of the Pathologic Features of Esophageal Squamous Cell Cancer: Tumor Budding Is a Significant Independent Prognostic FactorAnnals of Surgical Oncology, 15
-
A. Ben-Ze'ev (2018)
Faculty Opinions recommendation of Tumor budding: the name is EMT. partial EMT.Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
-
(Bosman, F. T., Organization, W. H. & Cancer IAfRo. in WHO Classification of Tumours of the Digestive System 4th edn (eds Bosman, F.T., Carneiro, F., Hruban, R.H. & Theise, N. D.) 417p (IARC Press, Lyon, 2010).)
Bosman, F. T., Organization, W. H. & Cancer IAfRo. in WHO Classification of Tumours of the Digestive System 4th edn (eds Bosman, F.T., Carneiro, F., Hruban, R.H. & Theise, N. D.) 417p (IARC Press, Lyon, 2010).Bosman, F. T., Organization, W. H. & Cancer IAfRo. in WHO Classification of Tumours of the Digestive System 4th edn (eds Bosman, F.T., Carneiro, F., Hruban, R.H. & Theise, N. D.) 417p (IARC Press, Lyon, 2010)., Bosman, F. T., Organization, W. H. & Cancer IAfRo. in WHO Classification of Tumours of the Digestive System 4th edn (eds Bosman, F.T., Carneiro, F., Hruban, R.H. & Theise, N. D.) 417p (IARC Press, Lyon, 2010).
-
J. Galván, I. Zlobec, Martin Wartenberg, A. Lugli, B. Gloor, A. Perren, E. Karamitopoulou (2015)
Expression of E-cadherin repressors SNAIL, ZEB1 and ZEB2 by tumour and stromal cells influences tumour-budding phenotype and suggests heterogeneity of stromal cells in pancreatic cancerBritish Journal of Cancer, 112
-
Matthew Brown, K. Sillah, E. Griffiths, R. Swindell, C. West, R. Page, I. Welch, S. Pritchard (2010)
Tumour budding and a low host inflammatory response are associated with a poor prognosis in oesophageal and gastro‐oesophageal junction cancersHistopathology, 56
-
Y. Yamaguchi, G. Ishii, M. Kojima, K. Yoh, Hajime Otsuka, Y. Otaki, K. Aokage, S. Yanagi, K. Nagai, Y. Nishiwaki, A. Ochiai (2010)
Histopathologic Features of the Tumor Budding in Adenocarcinoma of the Lung: Tumor Budding As an Index to Predict the Potential AggressivenessJournal of Thoracic Oncology, 5
-
(2009)
The basics of epithelial-mesenchymal transitionJ. Clin. Invest., 119
-
I. Kohler, P. Bronsert, S. Timme, M. Werner, T. Brabletz, U. Hopt, O. Schilling, D. Bausch, T. Keck, U. Wellner (2015)
Detailed analysis of epithelial‐mesenchymal transition and tumor budding identifies predictors of long‐term survival in pancreatic ductal adenocarcinomaJournal of Gastroenterology and Hepatology, 30
-
H. Gabbert, S. Meier, C. Gerharz, G. Hommel (1992)
Tumor‐cell dissociation at the invasion front: A new prognostic parameter in gastric cancer patientsInternational Journal of Cancer, 50
-
(2007)
Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trialJAMA, 297
-
(2016)
EMT: 2016Cell, 166
-
A. Lugli, R. Kirsch, Y. Ajioka, F. Bosman, G. Cathomas, H. Dawson, H. Zimaity, J. Fléjou, T. Hansen, A. Hartmann, S. Kakar, C. Langner, I. Nagtegaal, G. Puppa, R. Riddell, A. Ristimäki, K. Sheahan, T. Smyrk, K. Sugihara, B. Terris, H. Ueno, M. Vieth, I. Zlobec, P. Quirke (2017)
Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016Modern Pathology, 30
-
(2005)
REporting recommendations for tumour MARKer prognostic studies (REMARK)Br. J. Cancer, 93
-
E. Karamitopoulou, I. Zlobec, D. Born, A. Kondi‐Pafiti, P. Lykoudis, A. Mellou, K. Gennatas, B. Gloor, A. Lugli (2013)
Tumour budding is a strong and independent prognostic factor in pancreatic cancer.European journal of cancer, 49 5
-
N. Ohike, Ipek Coban, Grace Kim, O. Basturk, Takuma Tajiri, A. Krasinskas, S. Bandyopadhyay, T. Morohoshi, Y. Shimada, D. Kooby, C. Staley, M. Goodman, N. Adsay (2010)
Tumor Budding as a Strong Prognostic Indicator in Invasive Ampullary AdenocarcinomasThe American Journal of Surgical Pathology, 34
-
H. Miyata, Akiko Yoshioka, M. Yamasaki, Yoichiro Nushijima, S. Takiguchi, Y. Fujiwara, T. Nishida, M. Mano, M. Mori, Y. Doki (2009)
Tumor budding in tumor invasive front predicts prognosis and survival of patients with esophageal squamous cell carcinomas receiving neoadjuvant chemotherapyCancer, 115
-
P. Bronsert, K. Enderle-Ammour, M. Bader, S. Timme, M. Kuehs, Á. Csanádi, G. Kayser, I. Kohler, D. Bausch, J. Hoeppner, U. Hopt, T. Keck, E. Stickeler, Bernward Passlick, O. Schilling, CP Reiss, Y. Vashist, T. Brabletz, J. Berger, J. Lotz, J. Olesch, M. Werner, U. Wellner (2014)
Cancer cell invasion and EMT marker expression: a three‐dimensional study of the human cancer–host interfaceThe Journal of Pathology, 234
-
I. Zlobec, Marion Hädrich, H. Dawson, V. Koelzer, M. Borner, M. Mallaev, B. Schnüriger, D. Inderbitzin, A. Lugli (2013)
Intratumoural budding (ITB) in preoperative biopsies predicts the presence of lymph node and distant metastases in colon and rectal cancer patientsBritish Journal of Cancer, 110
-
O. Giger, Sarah Comtesse, A. Lugli, I. Zlobec, M. Kurrer (2012)
Intra-tumoral budding in preoperative biopsy specimens predicts lymph node and distant metastasis in patients with colorectal cancerModern Pathology, 25
-
S. Kazama, Takayuki Watanabe, Y. Ajioka, T. Kanazawa, H. Nagawa (2006)
Tumour budding at the deepest invasive margin correlates with lymph node metastasis in submucosal colorectal cancer detected by anticytokeratin antibody CAM5.2British Journal of Cancer, 94
-
Fenli Liang, W. Cao, Yili Wang, Linrui Li, Guanjun Zhang, Zhuo Wang (2013)
The prognostic value of tumor budding in invasive breast cancer.Pathology, research and practice, 209 5
-
H. Ueno, J. Murphy, J. Jass, H. Mochizuki, I. Talbot (2002)
Tumour `budding' as an index to estimate the potential of aggressiveness in rectal cancerHistopathology, 40
-
Y. Masugi, K. Yamazaki, T. Hibi, K. Aiura, Y. Kitagawa, M. Sakamoto (2010)
Solitary cell infiltration is a novel indicator of poor prognosis and epithelial-mesenchymal transition in pancreatic cancer.Human pathology, 41 8
-
(Arnoux, V., Come, C., Kusewitt, D. F., Hudson, L. G. & Savagner, P. in Rise and Fall of Epithelial Phenotype 1st edn. (ed Savagner, P.)111–134 (Springer, US, 2005).)
Arnoux, V., Come, C., Kusewitt, D. F., Hudson, L. G. & Savagner, P. in Rise and Fall of Epithelial Phenotype 1st edn. (ed Savagner, P.)111–134 (Springer, US, 2005).Arnoux, V., Come, C., Kusewitt, D. F., Hudson, L. G. & Savagner, P. in Rise and Fall of Epithelial Phenotype 1st edn. (ed Savagner, P.)111–134 (Springer, US, 2005)., Arnoux, V., Come, C., Kusewitt, D. F., Hudson, L. G. & Savagner, P. in Rise and Fall of Epithelial Phenotype 1st edn. (ed Savagner, P.)111–134 (Springer, US, 2005).
-
S. Paget (1989)
The distribution of secondary growths in cancer of the breast. 1889.Cancer metastasis reviews, 8 2
-
Günter Klöppel, G. Lingenthal, M. Bülow, H. Kern (1985)
Histological and fine structural features of pancreatic ductal adenocarcinomas in relation to growth and prognosis: studies in xenografted tumours and clinico‐histopathological correlation in a series of 75 casesHistopathology, 9
-
S. Heerboth, Genevieve Housman, M. Leary, Mckenna Longacre, Shannon Byler, K. Lapinska, A. Willbanks, S. Sarkar (2015)
EMT and tumor metastasisClinical and Translational Medicine, 4
-
(2005)
Rise and Fall of Epithelial Phenotype 1st edn -
V. Koelzer, I. Zlobec, M. Berger, G. Cathomas, H. Dawson, K. Dirschmid, Marion Hädrich, D. Inderbitzin, F. Offner, G. Puppa, W. Seelentag, B. Schnüriger, L. Tornillo, A. Lugli (2015)
Tumor budding in colorectal cancer revisited: results of a multicenter interobserver studyVirchows Archiv, 466
-
A. Harris, A. Harris (2005)
REporting recommendations for tumour MARKer prognostic studies (REMARK)British Journal of Cancer, 93
-
(2010)
Cancer IAfRo. in WHO Classification of Tumours of the Digestive System 4th edn
- Publisher
- Springer Journals
- Copyright
- Copyright © 2018 by Cancer Research UK
- Subject
- Biomedicine; Biomedicine, general; Cancer Research; Epidemiology; Molecular Medicine; Oncology; Drug Resistance
- ISSN
- 0007-0920
- eISSN
- 1532-1827
- DOI
- 10.1038/s41416-018-0093-y
- Publisher site
- See Article on Publisher Site
Abstract
www.nature.com/bjc ARTICLE Molecular Diagnostics Tumour buds determine prognosis in resected pancreatic ductal adenocarcinoma 1,2 3 4 3 3 3 1 3 Philipp Lohneis , Marianne Sinn , Fritz Klein , Sven Bischoff , Jana K. Striefler , Lilianna Wislocka , Bruno V. Sinn , Uwe Pelzer , 5 3 1 1 3 Helmut Oettle , Hanno Riess , Carsten Denkert , Hendrik Bläker and Anja Jühling BACKGROUND: The prognostic effect of tumour budding was retrospectively analysed in a cohort of 173 patients with resected pancreatic ductal adenocarcinomas (PDACs) of the prospective clinical multicentre CONKO-001 trial. METHODS: Haematoxylin and eosin (H&E)-stained whole tissue slides were evaluated. In two independent approaches, the mean number of tumour buds was analysed according to the consensus criteria in colorectal cancer, in one 0.785 mm field of view and additionally in 10 high-power fields (HPF) (HPF = 0.238 mm ). RESULTS: Tumour budding was significantly associated with a higher tumour grade (p < 0.001) but not with distant or lymph node metastasis. Regardless of the quantification approach, an increased number of tumour buds was significantly associated with reduced disease-free survival (DFS) and overall survival (OS) (10 HPF approach DFS: HR = 1.056 (95% CI 1.022–1.092),
Journal
British Journal of Cancer – Springer Journals
Published: May 14, 2018