Tumour buds determine prognosis in resected pancreatic ductal adenocarcinoma

Tumour buds determine prognosis in resected pancreatic ductal adenocarcinoma www.nature.com/bjc ARTICLE Molecular Diagnostics Tumour buds determine prognosis in resected pancreatic ductal adenocarcinoma 1,2 3 4 3 3 3 1 3 Philipp Lohneis , Marianne Sinn , Fritz Klein , Sven Bischoff , Jana K. Striefler , Lilianna Wislocka , Bruno V. Sinn , Uwe Pelzer , 5 3 1 1 3 Helmut Oettle , Hanno Riess , Carsten Denkert , Hendrik Bläker and Anja Jühling BACKGROUND: The prognostic effect of tumour budding was retrospectively analysed in a cohort of 173 patients with resected pancreatic ductal adenocarcinomas (PDACs) of the prospective clinical multicentre CONKO-001 trial. METHODS: Haematoxylin and eosin (H&E)-stained whole tissue slides were evaluated. In two independent approaches, the mean number of tumour buds was analysed according to the consensus criteria in colorectal cancer, in one 0.785 mm field of view and additionally in 10 high-power fields (HPF) (HPF = 0.238 mm ). RESULTS: Tumour budding was significantly associated with a higher tumour grade (p < 0.001) but not with distant or lymph node metastasis. Regardless of the quantification approach, an increased number of tumour buds was significantly associated with reduced disease-free survival (DFS) and overall survival (OS) (10 HPF approach DFS: HR = 1.056 (95% CI 1.022–1.092), http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Cancer Springer Journals
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Publisher
Nature Publishing Group UK
Copyright
Copyright © 2018 by Cancer Research UK
Subject
Biomedicine; Biomedicine, general; Cancer Research; Epidemiology; Molecular Medicine; Oncology; Drug Resistance
ISSN
0007-0920
eISSN
1532-1827
D.O.I.
10.1038/s41416-018-0093-y
Publisher site
See Article on Publisher Site

Abstract

www.nature.com/bjc ARTICLE Molecular Diagnostics Tumour buds determine prognosis in resected pancreatic ductal adenocarcinoma 1,2 3 4 3 3 3 1 3 Philipp Lohneis , Marianne Sinn , Fritz Klein , Sven Bischoff , Jana K. Striefler , Lilianna Wislocka , Bruno V. Sinn , Uwe Pelzer , 5 3 1 1 3 Helmut Oettle , Hanno Riess , Carsten Denkert , Hendrik Bläker and Anja Jühling BACKGROUND: The prognostic effect of tumour budding was retrospectively analysed in a cohort of 173 patients with resected pancreatic ductal adenocarcinomas (PDACs) of the prospective clinical multicentre CONKO-001 trial. METHODS: Haematoxylin and eosin (H&E)-stained whole tissue slides were evaluated. In two independent approaches, the mean number of tumour buds was analysed according to the consensus criteria in colorectal cancer, in one 0.785 mm field of view and additionally in 10 high-power fields (HPF) (HPF = 0.238 mm ). RESULTS: Tumour budding was significantly associated with a higher tumour grade (p < 0.001) but not with distant or lymph node metastasis. Regardless of the quantification approach, an increased number of tumour buds was significantly associated with reduced disease-free survival (DFS) and overall survival (OS) (10 HPF approach DFS: HR = 1.056 (95% CI 1.022–1.092),

Journal

British Journal of CancerSpringer Journals

Published: May 14, 2018

References

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