Analysis of microsatellite TNFa marker and (−308(G/A) polymorphisms in promoter of TNFa gene was conducted in 167 patients with various types of sporadic breast cancer (BC) as well as in 139 healthy Russian donors. It was shown that frequency of allele 7 in TNFa microsatellite marker was significantly higher in BC patients than in healthy donors (17.9% versus 10.4%; P = 0.02) mainly due to the patients with invasive ductal BC (19.2% versus 10.4%; P = 0.008). The TNFa allele 9 was observed significantly more frequently in patients with invasive-ductal cancer (6.4% versus 1%; p = 0.01). The studies of −308(G/A)TNFα polymorphism in BC patients and healthy donors have shown no differences in the distribution frequency of highly secreted allele (−308A)TNFα. However, invasive lobular BC patients carrying (−308AG)TNFα genotype were observed significantly more frequently than invasive-ductal BC patients carrying the same allele (34.0 versus 17.3%; P = 0.034). Thus it has been shown for the first time that invasive-ductal and invasive-lobular BC patients differ in distribution of TNFa and −308(G/A)TNFα alleles.
Russian Journal of Genetics – Springer Journals
Published: Sep 25, 2008
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