To investigate the role of tumor necrosis factor alpha (TNFα) in the pathogenesis of acute viral encephalitis, TNFα-deficient mice were infected with a highly neurovirulent strain of mouse hepatitis virus, JHM, and compared with JHM-infected C57BL/6 mice as controls. All the JHM-infected mice had succumbed to infection by 6 days postinfection. The virus replication kinetics, histopathological changes and mRNA expression levels of proinflammatory cytokines in the brain did not differ between TNFα-deficient and control C57BL/6 mice. These results suggest that TNFα is not a pathogenic determinant in JHM-induced acute lethal encephalitis.
Archives of Virology – Springer Journals
Published: Mar 1, 2008
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