Tumor necrosis factor alpha is not a pathogenic determinant in acute lethal encephalitis induced by a highly neurovirulent strain of mouse hepatitis virus

Tumor necrosis factor alpha is not a pathogenic determinant in acute lethal encephalitis induced... To investigate the role of tumor necrosis factor alpha (TNFα) in the pathogenesis of acute viral encephalitis, TNFα-deficient mice were infected with a highly neurovirulent strain of mouse hepatitis virus, JHM, and compared with JHM-infected C57BL/6 mice as controls. All the JHM-infected mice had succumbed to infection by 6 days postinfection. The virus replication kinetics, histopathological changes and mRNA expression levels of proinflammatory cytokines in the brain did not differ between TNFα-deficient and control C57BL/6 mice. These results suggest that TNFα is not a pathogenic determinant in JHM-induced acute lethal encephalitis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Tumor necrosis factor alpha is not a pathogenic determinant in acute lethal encephalitis induced by a highly neurovirulent strain of mouse hepatitis virus

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Publisher
Springer Vienna
Copyright
Copyright © 2008 by Springer-Verlag
Subject
Biomedicine; Infectious Diseases; Medical Microbiology ; Virology
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-007-0006-5
Publisher site
See Article on Publisher Site

Abstract

To investigate the role of tumor necrosis factor alpha (TNFα) in the pathogenesis of acute viral encephalitis, TNFα-deficient mice were infected with a highly neurovirulent strain of mouse hepatitis virus, JHM, and compared with JHM-infected C57BL/6 mice as controls. All the JHM-infected mice had succumbed to infection by 6 days postinfection. The virus replication kinetics, histopathological changes and mRNA expression levels of proinflammatory cytokines in the brain did not differ between TNFα-deficient and control C57BL/6 mice. These results suggest that TNFα is not a pathogenic determinant in JHM-induced acute lethal encephalitis.

Journal

Archives of VirologySpringer Journals

Published: Mar 1, 2008

References

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