Tumor Cell Dormancy—a Hallmark of Metastatic Growth and Disease Recurrence in Bone

Tumor Cell Dormancy—a Hallmark of Metastatic Growth and Disease Recurrence in Bone Purpose of Review Dormant disseminated tumor cells are thought to play a pivotal role in driving tumor growth in bone and are likely responsible for disease recurrence following chemotherapy; however, the mechanisms regulating these processes remain unclear. Herein, we discuss recent advances controlling the mechanisms of tumor cell dormancy in bone and discuss the clinical implications of these findings. Recent Findings Recent studies have defined gene expression signatures for dormant tumor cells in bone, identifying novel pathways that we can potentially exploit to target these cells. Using intravital imaging and cell fate tracking, bone cells within the bone microenvironment have been shown to play a critical role in regulating tumor cell dormancy and growth, highlighting local bone cell activity as a novel avenue to control tumor cell growth and a role for bone cell niches in supporting dormancy and treatment resistance. Summary Due to advances in pre-clinical imaging and sequencing tools, we have a greater understanding of the phenomenon of tumor cell dormancy in bone, ultimately opening avenues for novel targeted treatments. . . . . Keywords Tumor dormancy Bone metastases Bone microenvironment Treatment resistance Disease recurrence Introduction tion and treatment are limited. Research to-date has focused predominantly on http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Molecular Biology Reports Springer Journals

Tumor Cell Dormancy—a Hallmark of Metastatic Growth and Disease Recurrence in Bone

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Biomedicine; Molecular Medicine; Human Genetics
eISSN
2198-6428
D.O.I.
10.1007/s40610-018-0088-8
Publisher site
See Article on Publisher Site

Abstract

Purpose of Review Dormant disseminated tumor cells are thought to play a pivotal role in driving tumor growth in bone and are likely responsible for disease recurrence following chemotherapy; however, the mechanisms regulating these processes remain unclear. Herein, we discuss recent advances controlling the mechanisms of tumor cell dormancy in bone and discuss the clinical implications of these findings. Recent Findings Recent studies have defined gene expression signatures for dormant tumor cells in bone, identifying novel pathways that we can potentially exploit to target these cells. Using intravital imaging and cell fate tracking, bone cells within the bone microenvironment have been shown to play a critical role in regulating tumor cell dormancy and growth, highlighting local bone cell activity as a novel avenue to control tumor cell growth and a role for bone cell niches in supporting dormancy and treatment resistance. Summary Due to advances in pre-clinical imaging and sequencing tools, we have a greater understanding of the phenomenon of tumor cell dormancy in bone, ultimately opening avenues for novel targeted treatments. . . . . Keywords Tumor dormancy Bone metastases Bone microenvironment Treatment resistance Disease recurrence Introduction tion and treatment are limited. Research to-date has focused predominantly on

Journal

Current Molecular Biology ReportsSpringer Journals

Published: Mar 21, 2018

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