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Tube Formation Potential of BMSCs and USSCs in Response to HIF-1α Overexpression under Hypoxia

Tube Formation Potential of BMSCs and USSCs in Response to HIF-1α Overexpression under Hypoxia Despite numerous studies on therapeutic effects of mesenchymal stem cells on ischemic tissue regeneration, including angiogenesis, their mechanism of action remains ambiguous. Due to the scarce of investigations based on different stem cell sources with known inherent molecular differences, present study compare tube formation of Bone marrow Mesenchymal Stem Cells and Unrestricted Somatic Stem Cells with known reported different Hox gene expression profile in response to HIF-1α overexpression under hypoxia. This might shed light on some parameters for selection of more responsive source with improved therapeutic effects. Superior in vitro tube formation on Matrigel substratum has been observed by Unrestricted Somatic Stem Cells compared to Bone marrow Mesenchymal Stem Cells which might possibly be due to the discriminating molecular properties of stem cell sources. It may help choosing the appropriate stem cell type for a given therapeutic expectations and also suggests some potential targets for future genetic modification of stem cells. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cytology and Genetics Springer Journals

Tube Formation Potential of BMSCs and USSCs in Response to HIF-1α Overexpression under Hypoxia

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Allerton Press, Inc.
Subject
Biomedicine; Human Genetics
ISSN
0095-4527
eISSN
1934-9440
DOI
10.3103/S0095452718030064
Publisher site
See Article on Publisher Site

Abstract

Despite numerous studies on therapeutic effects of mesenchymal stem cells on ischemic tissue regeneration, including angiogenesis, their mechanism of action remains ambiguous. Due to the scarce of investigations based on different stem cell sources with known inherent molecular differences, present study compare tube formation of Bone marrow Mesenchymal Stem Cells and Unrestricted Somatic Stem Cells with known reported different Hox gene expression profile in response to HIF-1α overexpression under hypoxia. This might shed light on some parameters for selection of more responsive source with improved therapeutic effects. Superior in vitro tube formation on Matrigel substratum has been observed by Unrestricted Somatic Stem Cells compared to Bone marrow Mesenchymal Stem Cells which might possibly be due to the discriminating molecular properties of stem cell sources. It may help choosing the appropriate stem cell type for a given therapeutic expectations and also suggests some potential targets for future genetic modification of stem cells.

Journal

Cytology and GeneticsSpringer Journals

Published: Jun 4, 2018

References