J Endocrinol Invest (2018) 41:389–393 https://doi.org/10.1007/s40618-017-0752-5 ORIGINAL ARTICLE TSH oscillations in young patients with type 1 diabetes may be due to glycemic variability 1 1 1 1 1 G. Bellastella · M. I. Maiorino · L. Scappaticcio · O. Casciano · M. Petrizzo · 1 1 1 2 M. Caputo · V. A. Paglionico · D. Giugliano · K. Esposito Received: 8 August 2017 / Accepted: 20 August 2017 / Published online: 30 August 2017 © Italian Society of Endocrinology (SIE) 2017 Abstract correlation was observed between TSH levels and glycemic Purpose A relationship between thyroid dysfunction and values (r = −0.27; p = 0.01), CONGA index (r = −0.35; diabetes mellitus has been described by several authors but p = 0.001) and HBGI (r = −0.28; p = 0.01) but not with the role of glycemic variability is still unclear. We planned HbA1c (r = −0.1; p = 0.47). the present study to evaluate the influence of glycemic Conclusions Our results suggest a direct action of glyce- variability on thyroid hormones and TSH concentrations in mic excursions on TSH secretion, regardless of variations patients with type 1 diabetes mellitus (T1DM). of thyroid hormone concentrations. Thus, the evaluation of Methods Seventy-seven young patients with T1DM were thyroid function through the assay of TSH concentrations in enrolled and evaluated for basal glucose concentrations, these patients should be made, if
Journal of Endocrinological Investigation – Springer Journals
Published: Aug 30, 2017
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