Ann Surg Oncol (2018) 25:2083–2090 https://doi.org/10.1245/s10434-018-6480-z O R I G IN AL ARTI CL E – TRAN SLATIO NA L R ESEA RCH AN D B IOM A RK ERS Troponin I2 as a Speciﬁc Biomarker for Prediction of Peritoneal Metastasis in Gastric Cancer Koichi Sawaki, MD, Mitsuro Kanda, MD, PhD, FACS, Takashi Miwa, MD, Shinichi Umeda, MD, Haruyoshi Tanaka, MD, Chie Tanaka, MD, PhD, Daisuke Kobayashi, MD, PhD, Masaya Suenaga, MD, PhD, Norifumi Hattori, MD, PhD, Masamichi Hayashi, MD, PhD, Suguru Yamada, MD, PhD, FACS, Goro Nakayama, MD, PhD, Michitaka Fujiwara, MD, PhD, and Yasuhiro Kodera, MD, PhD, FACS Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Japan ABSTRACT correlation coefﬁcient[ 0.7. The optimal cutoff of TNNI2 Background. Although peritoneal metastasis is a serious expression was determined as 0.00017. High TNNI2 concern in patients with gastric cancer, no acceptable and expression was signiﬁcantly and speciﬁcally associated speciﬁc biomarker is available. We aimed to identify a with peritoneal metastasis and served as an independent candidate biomarker to predict peritoneal metastasis of risk marker for peritoneal recurrence after curative gas- gastric cancer. trectomy. Prevalence of peritoneal recurrence increased in Methods. Metastatic pathway-speciﬁc transcriptome parallel with
Annals of Surgical Oncology – Springer Journals
Published: Apr 16, 2018
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