Childs Nerv Syst (2017) 33:1463–1471 DOI 10.1007/s00381-017-3506-y ORIGINAL PAPER Tropomyosin receptor kinase C (TrkC) expression in medulloblastoma: relation to the molecular subgroups and impact on treatment response 1,2 3 4,5 6 Carsten Friedrich & Tarek Shalaby & Christoph Oehler & Martin Pruschy & 7 8,9,10 8,9,10 11 Burkhardt Seifert & Daniel Picard & Marc Remke & Monika Warmuth-Metz & 12 13 3 Rolf-Dieter Kortmann & Stefan Rutkowski & Michael A. Grotzer & 13,14,15,16 André O. von Bueren Received: 9 May 2017 /Accepted: 27 June 2017 /Published online: 10 July 2017 Springer-Verlag GmbH Germany 2017 Abstract and compared to a control (clone DAOY-EV, empty vector Purpose High messenger RNA (mRNA) expression of the transfected). Cell viability (MTS assay) was tested after irra- tropomyosin receptor kinase C gene (TrkC) has been associ- diation or incubation with chemotherapeutic drugs. ated with favorable survival in medulloblastoma patients. Neuroradiologic response to postoperative chemotherapy or Untested is whether it plays a role through modulating the craniospinal irradiation (CSI) of medulloblastoma patients response to therapy or whether it might be a surrogate marker aged 3–21 years with postoperative residual disease treated for a favorable molecular subgroup. within the consecutive trials HIT’91/HIT2000 was compared Methods The medulloblastoma-derived
Child's Nervous System – Springer Journals
Published: Jul 10, 2017
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