Triple-Layer Vascular Grafts Fabricated by Combined E-Jet 3D Printing and Electrospinning

Triple-Layer Vascular Grafts Fabricated by Combined E-Jet 3D Printing and Electrospinning Annals of Biomedical Engineering ( 2018) https://doi.org/10.1007/s10439-018-2065-z Triple-Layer Vascular Grafts Fabricated by Combined E-Jet 3D Printing and Electrospinning RUIYING HUANG,XIANGKAI GAO,JIAN WANG,HAOXIANG CHEN,CHUNYI TONG,YONGJUN TAN, and ZHIKAI TAN College of Biology, Hunan University, Changsha 410082, Hunan, China (Received 6 February 2018; accepted 25 May 2018) Associate Editor Kent Leach oversaw the review of this article. Abstract—Small-diameter tissue-engineered vascular grafts regenerative medicine and a critical way of biomedical are urgently needed for clinic arterial substitute. To simulate regeneration. As observed in situ, tissues are embed- the structures and functions of natural blood vessels, we ded in highly aligned basement membranes, sur- designed a novel triple-layer poly(e-caprolactone) (PCL) rounded by a complex formation of extracellular fibrous vascular graft by combining E-jet 3D printing and matrix (ECM) proteins comprising well-organized electrospinning techniques. The resultant vascular graft consisted of an interior layer comprising 3D-printed highly functional fibers. For instance, the tunica intima of aligned strong fibers, a middle layer made by electrospun vessels is coated with an anti-thrombogenic layer of densely fibers, and an exterior structure composed of mixed 4 longitudinally-orientated endothelial cells, the align- fibers fabricated by co-electrospraying. The biocompatible ment and orientation of the structural features of triple-layer graft was used http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Biomedical Engineering Springer Journals

Triple-Layer Vascular Grafts Fabricated by Combined E-Jet 3D Printing and Electrospinning

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Publisher
Springer US
Copyright
Copyright © 2018 by Biomedical Engineering Society
Subject
Biomedicine; Biomedicine, general; Biomedical Engineering; Biological and Medical Physics, Biophysics; Classical Mechanics; Biochemistry, general
ISSN
0090-6964
eISSN
1573-9686
D.O.I.
10.1007/s10439-018-2065-z
Publisher site
See Article on Publisher Site

Abstract

Annals of Biomedical Engineering ( 2018) https://doi.org/10.1007/s10439-018-2065-z Triple-Layer Vascular Grafts Fabricated by Combined E-Jet 3D Printing and Electrospinning RUIYING HUANG,XIANGKAI GAO,JIAN WANG,HAOXIANG CHEN,CHUNYI TONG,YONGJUN TAN, and ZHIKAI TAN College of Biology, Hunan University, Changsha 410082, Hunan, China (Received 6 February 2018; accepted 25 May 2018) Associate Editor Kent Leach oversaw the review of this article. Abstract—Small-diameter tissue-engineered vascular grafts regenerative medicine and a critical way of biomedical are urgently needed for clinic arterial substitute. To simulate regeneration. As observed in situ, tissues are embed- the structures and functions of natural blood vessels, we ded in highly aligned basement membranes, sur- designed a novel triple-layer poly(e-caprolactone) (PCL) rounded by a complex formation of extracellular fibrous vascular graft by combining E-jet 3D printing and matrix (ECM) proteins comprising well-organized electrospinning techniques. The resultant vascular graft consisted of an interior layer comprising 3D-printed highly functional fibers. For instance, the tunica intima of aligned strong fibers, a middle layer made by electrospun vessels is coated with an anti-thrombogenic layer of densely fibers, and an exterior structure composed of mixed 4 longitudinally-orientated endothelial cells, the align- fibers fabricated by co-electrospraying. The biocompatible ment and orientation of the structural features of triple-layer graft was used

Journal

Annals of Biomedical EngineeringSpringer Journals

Published: May 29, 2018

References

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