Treatments for TD: limited evidence, high cost

Treatments for TD: limited evidence, high cost PharmacoEconomics & Outcomes News 792, p4 - 2 Dec 2017 Treatments for TD: limited evidence, high cost The evidence of the clinical benefit and long-term safety of valbenazine and deutetrabenazine for the treatment of tardive dyskinesia (TD) is uncertain, and these agents are not cost effective at current wholesale acquisition cost (WAC). These are the main findings of an evidence report, released by the Institute for Clinical and Economic Review (ICER), which assessed the comparative clinical effectiveness and value of valbenazine [Ingrezza], deutetrabenazine [Austedo] and tetrabenazine [Xenazine] for management of TD. For valbenazine and deutetrabenazine, the report found inconclusive evidence for the treatment of TD, mainly due to uncertainty surrounding key outcome measures studied in clinical trials, as well as a lack of long-term safety data. For tetrabenazine, the evidence was insufficient to assess its net health benefit. Economic analyses showed that both valbenazine and deutetrabenazine were not cost effective at $US752 000 and $1.1 million per QALY, respectively. The analyses also showed that the annual WAC of valbenazine (currently $76 000) would need to fall to $7600–$11 260, a discount of 85%–90%, to align the cost with the benefit provided to patients. Similarly, the annual WAC of deutetrabenazine (currently $90 000) would need to fall to $6200–$9200, a discount of 90%–93%. Tetrabenazine was not included in these economic analyses due to data limitations. ICER. Institute for Clinical and Economic Review report finds evidence limited on treatments for tardive dyskinesia; discounts of up to 90% needed to align cost of drugs with benefit to patients. Internet Document : 21 Nov 2017. Available from: URL: https://icer-review.org/announcements/tardive-dyskinesia-evidence-report/ 1173-5503/17/0792-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved PharmacoEconomics & Outcomes News 2 Dec 2017 No. 792 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png PharmacoEconomics & Outcomes News Springer Journals

Treatments for TD: limited evidence, high cost

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Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Pharmacoeconomics and Health Outcomes; Quality of Life Research; Health Economics; Public Health
ISSN
1173-5503
eISSN
1179-2043
D.O.I.
10.1007/s40274-017-4527-1
Publisher site
See Article on Publisher Site

Abstract

PharmacoEconomics & Outcomes News 792, p4 - 2 Dec 2017 Treatments for TD: limited evidence, high cost The evidence of the clinical benefit and long-term safety of valbenazine and deutetrabenazine for the treatment of tardive dyskinesia (TD) is uncertain, and these agents are not cost effective at current wholesale acquisition cost (WAC). These are the main findings of an evidence report, released by the Institute for Clinical and Economic Review (ICER), which assessed the comparative clinical effectiveness and value of valbenazine [Ingrezza], deutetrabenazine [Austedo] and tetrabenazine [Xenazine] for management of TD. For valbenazine and deutetrabenazine, the report found inconclusive evidence for the treatment of TD, mainly due to uncertainty surrounding key outcome measures studied in clinical trials, as well as a lack of long-term safety data. For tetrabenazine, the evidence was insufficient to assess its net health benefit. Economic analyses showed that both valbenazine and deutetrabenazine were not cost effective at $US752 000 and $1.1 million per QALY, respectively. The analyses also showed that the annual WAC of valbenazine (currently $76 000) would need to fall to $7600–$11 260, a discount of 85%–90%, to align the cost with the benefit provided to patients. Similarly, the annual WAC of deutetrabenazine (currently $90 000) would need to fall to $6200–$9200, a discount of 90%–93%. Tetrabenazine was not included in these economic analyses due to data limitations. ICER. Institute for Clinical and Economic Review report finds evidence limited on treatments for tardive dyskinesia; discounts of up to 90% needed to align cost of drugs with benefit to patients. Internet Document : 21 Nov 2017. Available from: URL: https://icer-review.org/announcements/tardive-dyskinesia-evidence-report/ 1173-5503/17/0792-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved PharmacoEconomics & Outcomes News 2 Dec 2017 No. 792

Journal

PharmacoEconomics & Outcomes NewsSpringer Journals

Published: Dec 2, 2017

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