Am J Cardiovasc Drugs (2018) 18:397–403 https://doi.org/10.1007/s40256-018-0285-0 ORIGINAL RESEARCH ARTICLE Treatment with Mannitol is Associated with Increased Risk for In-Hospital Mortality in Patients with Acute Ischemic Stroke and Cerebral Edema 1 1 1 • • • Marianthi Papagianni Konstantinos Tziomalos Stavroula Kostaki 1 1 1 • • • Stella-Maria Angelopoulou Konstantinos Christou Stella D. Bouziana 1 1 1 • • • Maria Vergou Triantafyllos Didangelos Christos Savopoulos Apostolos I. Hatzitolios Published online: 30 May 2018 Springer International Publishing AG, part of Springer Nature 2018 Abstract Conclusions Administration of mannitol to patients with Background Current guidelines state that osmotic therapy ischemic stroke-related cerebral edema does not appear to is reasonable in patients with clinical deterioration from affect the functional outcome and might increase mortality, cerebral infarction-related cerebral edema. However, there independently of stroke severity. are limited data on the safety and efﬁcacy of this therapy. We aimed to evaluate the effect of mannitol on the out- come of ischemic stroke-related cerebral edema. Key Points Methods and Results We prospectively studied 922 con- secutive patients admitted with acute ischemic stroke. In patients with cerebral edema due to acute Patients who showed space-occupying brain edema with ischemic stroke, mannitol does not appear
American Journal of Cardiovascular Drugs – Springer Journals
Published: May 30, 2018
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