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Treatment with Mannitol is Associated with Increased Risk for In-Hospital Mortality in Patients with Acute Ischemic Stroke and Cerebral Edema

Treatment with Mannitol is Associated with Increased Risk for In-Hospital Mortality in Patients... Am J Cardiovasc Drugs (2018) 18:397–403 https://doi.org/10.1007/s40256-018-0285-0 ORIGINAL RESEARCH ARTICLE Treatment with Mannitol is Associated with Increased Risk for In-Hospital Mortality in Patients with Acute Ischemic Stroke and Cerebral Edema 1 1 1 • • • Marianthi Papagianni Konstantinos Tziomalos Stavroula Kostaki 1 1 1 • • • Stella-Maria Angelopoulou Konstantinos Christou Stella D. Bouziana 1 1 1 • • • Maria Vergou Triantafyllos Didangelos Christos Savopoulos Apostolos I. Hatzitolios Published online: 30 May 2018 Springer International Publishing AG, part of Springer Nature 2018 Abstract Conclusions Administration of mannitol to patients with Background Current guidelines state that osmotic therapy ischemic stroke-related cerebral edema does not appear to is reasonable in patients with clinical deterioration from affect the functional outcome and might increase mortality, cerebral infarction-related cerebral edema. However, there independently of stroke severity. are limited data on the safety and efficacy of this therapy. We aimed to evaluate the effect of mannitol on the out- come of ischemic stroke-related cerebral edema. Key Points Methods and Results We prospectively studied 922 con- secutive patients admitted with acute ischemic stroke. In patients with cerebral edema due to acute Patients who showed space-occupying brain edema with ischemic stroke, mannitol does not appear http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Cardiovascular Drugs Springer Journals

Treatment with Mannitol is Associated with Increased Risk for In-Hospital Mortality in Patients with Acute Ischemic Stroke and Cerebral Edema

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Cardiology; Pharmacotherapy; Pharmacology/Toxicology
ISSN
1175-3277
eISSN
1179-187X
DOI
10.1007/s40256-018-0285-0
Publisher site
See Article on Publisher Site

Abstract

Am J Cardiovasc Drugs (2018) 18:397–403 https://doi.org/10.1007/s40256-018-0285-0 ORIGINAL RESEARCH ARTICLE Treatment with Mannitol is Associated with Increased Risk for In-Hospital Mortality in Patients with Acute Ischemic Stroke and Cerebral Edema 1 1 1 • • • Marianthi Papagianni Konstantinos Tziomalos Stavroula Kostaki 1 1 1 • • • Stella-Maria Angelopoulou Konstantinos Christou Stella D. Bouziana 1 1 1 • • • Maria Vergou Triantafyllos Didangelos Christos Savopoulos Apostolos I. Hatzitolios Published online: 30 May 2018 Springer International Publishing AG, part of Springer Nature 2018 Abstract Conclusions Administration of mannitol to patients with Background Current guidelines state that osmotic therapy ischemic stroke-related cerebral edema does not appear to is reasonable in patients with clinical deterioration from affect the functional outcome and might increase mortality, cerebral infarction-related cerebral edema. However, there independently of stroke severity. are limited data on the safety and efficacy of this therapy. We aimed to evaluate the effect of mannitol on the out- come of ischemic stroke-related cerebral edema. Key Points Methods and Results We prospectively studied 922 con- secutive patients admitted with acute ischemic stroke. In patients with cerebral edema due to acute Patients who showed space-occupying brain edema with ischemic stroke, mannitol does not appear

Journal

American Journal of Cardiovascular DrugsSpringer Journals

Published: May 30, 2018

References