Am J Cardiovasc Drugs (2018) 18:397–403 https://doi.org/10.1007/s40256-018-0285-0 ORIGINAL RESEARCH ARTICLE Treatment with Mannitol is Associated with Increased Risk for In-Hospital Mortality in Patients with Acute Ischemic Stroke and Cerebral Edema 1 1 1 • • • Marianthi Papagianni Konstantinos Tziomalos Stavroula Kostaki 1 1 1 • • • Stella-Maria Angelopoulou Konstantinos Christou Stella D. Bouziana 1 1 1 • • • Maria Vergou Triantafyllos Didangelos Christos Savopoulos Apostolos I. Hatzitolios Published online: 30 May 2018 Springer International Publishing AG, part of Springer Nature 2018 Abstract Conclusions Administration of mannitol to patients with Background Current guidelines state that osmotic therapy ischemic stroke-related cerebral edema does not appear to is reasonable in patients with clinical deterioration from affect the functional outcome and might increase mortality, cerebral infarction-related cerebral edema. However, there independently of stroke severity. are limited data on the safety and efﬁcacy of this therapy. We aimed to evaluate the effect of mannitol on the out- come of ischemic stroke-related cerebral edema. Key Points Methods and Results We prospectively studied 922 con- secutive patients admitted with acute ischemic stroke. In patients with cerebral edema due to acute Patients who showed space-occupying brain edema with ischemic stroke, mannitol does not appear
American Journal of Cardiovascular Drugs – Springer Journals
Published: May 30, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
All the latest content is available, no embargo periods.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud