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Treatment with Botulinum Toxin for Refractory Fever Caused by Severe Spasticity: A Case Series

Treatment with Botulinum Toxin for Refractory Fever Caused by Severe Spasticity: A Case Series Neurol Ther (2018) 7:155–159 https://doi.org/10.1007/s40120-018-0092-1 CASE SERIES Treatment with Botulinum Toxin for Refractory Fever Caused by Severe Spasticity: A Case Series . . . Jacobo Lester Gerardo Esteban Alvarez-Resendiz Enrique Kle ´ riga Fernando Videgaray Gerardo Zambito Received: November 4, 2017 / Published online: January 30, 2018 The Author(s) 2018. This article is an open access publication usual drugs used for hyperpyrexia, type A ABSTRACT botulinum toxin may be an effective treatment option to control both spasticity and fever. Introduction: Brain and spinal cord injuries may cause very severe spasticity that occasion- Keywords: Botulinum toxin; Fever; Spasticity ally may be associated with persistent fever. Case Series: We present 14 patients with spas- ticity and persistent fever, treated with botuli- INTRODUCTION num toxin type A. Their spasticity improved and the fever resolved within a period no The hypothalamus is the regulatory center for greater than 48 h. In all cases, infectious and body temperature in humans [1], although the other non-infectious causes were ruled out. diencephalon and spinal cord also contribute Conclusions: When sustained tonic muscular [2]. If one of these structures is damaged, tem- activity is associated with a significant increase perature elevations above 38.3 C can occur [3]. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neurology and Therapy Springer Journals

Treatment with Botulinum Toxin for Refractory Fever Caused by Severe Spasticity: A Case Series

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Publisher
Springer Journals
Copyright
Copyright © 2018 by The Author(s)
Subject
Medicine & Public Health; Internal Medicine; Neurology
ISSN
2193-8253
eISSN
2193-6536
DOI
10.1007/s40120-018-0092-1
Publisher site
See Article on Publisher Site

Abstract

Neurol Ther (2018) 7:155–159 https://doi.org/10.1007/s40120-018-0092-1 CASE SERIES Treatment with Botulinum Toxin for Refractory Fever Caused by Severe Spasticity: A Case Series . . . Jacobo Lester Gerardo Esteban Alvarez-Resendiz Enrique Kle ´ riga Fernando Videgaray Gerardo Zambito Received: November 4, 2017 / Published online: January 30, 2018 The Author(s) 2018. This article is an open access publication usual drugs used for hyperpyrexia, type A ABSTRACT botulinum toxin may be an effective treatment option to control both spasticity and fever. Introduction: Brain and spinal cord injuries may cause very severe spasticity that occasion- Keywords: Botulinum toxin; Fever; Spasticity ally may be associated with persistent fever. Case Series: We present 14 patients with spas- ticity and persistent fever, treated with botuli- INTRODUCTION num toxin type A. Their spasticity improved and the fever resolved within a period no The hypothalamus is the regulatory center for greater than 48 h. In all cases, infectious and body temperature in humans [1], although the other non-infectious causes were ruled out. diencephalon and spinal cord also contribute Conclusions: When sustained tonic muscular [2]. If one of these structures is damaged, tem- activity is associated with a significant increase perature elevations above 38.3 C can occur [3].

Journal

Neurology and TherapySpringer Journals

Published: Jan 30, 2018

References