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- Publisher
- Springer Journals
- Copyright
- Copyright © 2018 by The Author(s)
- Subject
- Medicine & Public Health; Internal Medicine; Neurology
- ISSN
- 2193-8253
- eISSN
- 2193-6536
- DOI
- 10.1007/s40120-018-0092-1
- Publisher site
- See Article on Publisher Site
Abstract
Neurol Ther (2018) 7:155–159 https://doi.org/10.1007/s40120-018-0092-1 CASE SERIES Treatment with Botulinum Toxin for Refractory Fever Caused by Severe Spasticity: A Case Series . . . Jacobo Lester Gerardo Esteban Alvarez-Resendiz Enrique Kle ´ riga Fernando Videgaray Gerardo Zambito Received: November 4, 2017 / Published online: January 30, 2018 The Author(s) 2018. This article is an open access publication usual drugs used for hyperpyrexia, type A ABSTRACT botulinum toxin may be an effective treatment option to control both spasticity and fever. Introduction: Brain and spinal cord injuries may cause very severe spasticity that occasion- Keywords: Botulinum toxin; Fever; Spasticity ally may be associated with persistent fever. Case Series: We present 14 patients with spas- ticity and persistent fever, treated with botuli- INTRODUCTION num toxin type A. Their spasticity improved and the fever resolved within a period no The hypothalamus is the regulatory center for greater than 48 h. In all cases, infectious and body temperature in humans [1], although the other non-infectious causes were ruled out. diencephalon and spinal cord also contribute Conclusions: When sustained tonic muscular [2]. If one of these structures is damaged, tem- activity is associated with a significant increase perature elevations above 38.3 C can occur [3].
Journal
Neurology and Therapy – Springer Journals
Published: Jan 30, 2018