Treatment of refractory autoimmune hemolytic anemia with venetoclax in relapsed chronic lymphocytic leukemia with del(17p)

Treatment of refractory autoimmune hemolytic anemia with venetoclax in relapsed chronic... Ann Hematol (2017) 96:1577–1578 DOI 10.1007/s00277-017-3039-1 LETTER TO THE EDITOR Treatment of refractory autoimmune hemolytic anemia with venetoclax in relapsed chronic lymphocytic leukemia with del(17p) 1 1 1 Marcelo Pitombeira de Lacerda & Nayara Ribeiro Guedes & Patricia Eiko Yamakawa & 1 1 Andre Domingues Pereira & Ana Rita Brito Medeiros da Fonseca & 1 1 Maria Lourdes Lopes Ferrari de Chauffaille & Matheus Vescovi Goncalves & 1 1 Mihoko Yamamoto & Celso Arrais Rodrigues Received: 7 May 2017 /Accepted: 26 May 2017 /Published online: 9 June 2017 Springer-Verlag Berlin Heidelberg 2017 Dear editor, weeks. After 3 months, he showed improvement of symptoms We present the case of a 68-year-old male with chronic lym- and sustained hemoglobin levels, with no transfusion require- phocytic leukemia (CLL). He was diagnosed with CLL in ment. His latest flow cytometry study showed 0.05% CLL September 2007 and del (17p) was detected by FISH. In cells in peripheral blood. No CMV reactivation occurred. 2008, due to progressive splenomegaly, he received six cycles Two episodes of neutropenia were observed, without fever of fludarabine and cyclophosphamide and achieved complete or documented infection, responding to venetoclax interrup- response. In July 2015, he relapsed with progressive lympho- tion http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Hematology Springer Journals

Treatment of refractory autoimmune hemolytic anemia with venetoclax in relapsed chronic lymphocytic leukemia with del(17p)

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Subject
Medicine & Public Health; Hematology; Oncology
ISSN
0939-5555
eISSN
1432-0584
D.O.I.
10.1007/s00277-017-3039-1
Publisher site
See Article on Publisher Site

Abstract

Ann Hematol (2017) 96:1577–1578 DOI 10.1007/s00277-017-3039-1 LETTER TO THE EDITOR Treatment of refractory autoimmune hemolytic anemia with venetoclax in relapsed chronic lymphocytic leukemia with del(17p) 1 1 1 Marcelo Pitombeira de Lacerda & Nayara Ribeiro Guedes & Patricia Eiko Yamakawa & 1 1 Andre Domingues Pereira & Ana Rita Brito Medeiros da Fonseca & 1 1 Maria Lourdes Lopes Ferrari de Chauffaille & Matheus Vescovi Goncalves & 1 1 Mihoko Yamamoto & Celso Arrais Rodrigues Received: 7 May 2017 /Accepted: 26 May 2017 /Published online: 9 June 2017 Springer-Verlag Berlin Heidelberg 2017 Dear editor, weeks. After 3 months, he showed improvement of symptoms We present the case of a 68-year-old male with chronic lym- and sustained hemoglobin levels, with no transfusion require- phocytic leukemia (CLL). He was diagnosed with CLL in ment. His latest flow cytometry study showed 0.05% CLL September 2007 and del (17p) was detected by FISH. In cells in peripheral blood. No CMV reactivation occurred. 2008, due to progressive splenomegaly, he received six cycles Two episodes of neutropenia were observed, without fever of fludarabine and cyclophosphamide and achieved complete or documented infection, responding to venetoclax interrup- response. In July 2015, he relapsed with progressive lympho- tion

Journal

Annals of HematologySpringer Journals

Published: Jun 9, 2017

References

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