Of 49 patients to undergo parotidectomy during the past 6 years in our department, 18 (36.7%) subsequently noticed gustatory sweating. Of those 18, ten (20.4%) considered the sweating to be severe and very uncomfortable. Nine of the patients underwent Minor’s starch iodine test and Frey’s syndrome was confirmed. These patients were treated with an intracutaneous injection of 2.5 IU of botulinum toxin A (Botox, Allergan, USA) into the affected skin area. It was necessary to reinject the medicine into a small temporal hair-covered area in one patient, in whom Minor’s test did not appear clearly positive. The patients were subsequently evaluated with Minor’s test at 1 week, and then at 2, 6, 12 and 14 months, and were shown to be free of symptoms without any side effects. This preliminary report confirms that an intracutaneous injection of BT is an effective and safe treatment option for Frey’s syndrome. Further follow-up of the patients will be required to evaluate the duration of the therapeutic effect.
European Journal of Plastic Surgery – Springer Journals
Published: Oct 23, 2001
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