Transmitter Modulation of Neuronal Calcium Channels

Transmitter Modulation of Neuronal Calcium Channels J. Membrane Biol. 155, 1–10 (1997) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1997 Topical Review 1 2 S.W. Jones, K.S. Elmslie Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106 Department of Physiology, Tulane University, New Orleans, LA 70112 Received: 5 June 1996/Revised: 26 August 1996 Introduction The predominant effect of neurotransmitters on neu- ronal calcium channels is inhibitory (for general reviews, see Anwyl, 1991; Dolphin, 1991, 1995; Hille, 1994). In Calcium channels play many roles in neurons, but their most but not all cases, the effect is associated with slower most crucial function is in excitation-secretion coupling rates of channel activation, and a shift of activation to (Hille, 1992). An action potential arriving at a nerve more positive voltages (Bean, 1989; Grassi & Lux, 1989; terminal triggers release of neurotransmitter within a Elmslie et al., 1990). It is striking that the inhibition is millisecond, depending critically on highly localized in- 2+ incomplete, with effects at maximal transmitter concen- flux of Ca through voltage-dependent calcium chan- 2+ tration varying greatly, typically 20% to 90% inhibition. nels. The release of neurotransmitter depends on Ca in 2+ Initially, that was explained by selective block The Journal of Membrane Biology Springer Journals

Transmitter Modulation of Neuronal Calcium Channels

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Copyright © Inc. by 1997 Springer-Verlag New York
Life Sciences; Biochemistry, general; Human Physiology
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