Transmission of classical scrapie to wild-type mice: the influence of the ovine PrP sequence on lesion profiles

Transmission of classical scrapie to wild-type mice: the influence of the ovine PrP sequence on... Susceptibility of sheep to classical scrapie is determined by polymorphisms in the coding region of the prion protein gene ( PRNP ), mainly at codons 136, 154 and 171. It has recently been shown that lesion profiles from classical field scrapie isolates that transmitted to RIII mice can be classified into different groups. There was also strong, but not absolute, association between the different groups and codon 136. Here, we examine the hypothesis that additional polymorphisms in the open reading frame sequence of the ovine PRNP may account for the different groups of lesion profiles observed following transmission to mice. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Transmission of classical scrapie to wild-type mice: the influence of the ovine PrP sequence on lesion profiles

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Publisher
Springer Journals
Copyright
Copyright © 2011 by Springer-Verlag
Subject
Biomedicine; Medical Microbiology ; Infectious Diseases; Virology
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-011-0922-2
Publisher site
See Article on Publisher Site

Abstract

Susceptibility of sheep to classical scrapie is determined by polymorphisms in the coding region of the prion protein gene ( PRNP ), mainly at codons 136, 154 and 171. It has recently been shown that lesion profiles from classical field scrapie isolates that transmitted to RIII mice can be classified into different groups. There was also strong, but not absolute, association between the different groups and codon 136. Here, we examine the hypothesis that additional polymorphisms in the open reading frame sequence of the ovine PRNP may account for the different groups of lesion profiles observed following transmission to mice.

Journal

Archives of VirologySpringer Journals

Published: May 1, 2011

References

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