Transient IgG deficiency with lesions in brain and spinal cord: a mimicker of common variable immunodeficiency syndrome

Transient IgG deficiency with lesions in brain and spinal cord: a mimicker of common variable... Acta Neurol Belg (2017) 117:761–763 DOI 10.1007/s13760-016-0722-2 LETTER TO THE EDITOR Transient IgG deficiency with lesions in brain and spinal cord: a mimicker of common variable immunodeficiency syndrome 1 2 3 • • Konark Malhotra Ramnath Santosh Ramanathan Thomas F. Scott Received: 5 September 2016 / Accepted: 5 November 2016 / Published online: 15 November 2016 Belgian Neurological Society 2016 Introduction travel history, skin rash or any tick bites prior to admission. Her neurological exam was negative for bulbar signs, sensory Patients with immune deficiency states often present with abnormalities, sphincter dysfunction or meningismus. MRI- clinical perplexing disease processes, especially involving brain and spine with contrast demonstrated an extensive lesions of the central nervous system (CNS). Common vari- infiltrative process involving basal ganglia, hypothalamus and able immune deficiency (CVID) is a rare primary immune conus medullaris, with enhancing lesions in the upper cervical deficiency disorder that is usually associated with multi-organ cord and conus medullaris (Fig. 1a–c). Our clinical and radi- reversible inflammatory granulomatous lesions, though rarely ological differential diagnosis primarily included lymphoma, present with CNS manifestations. CNS involvement in CVID neurosarcoidosis, and infectious granulomatous diseases. can mimic neuroinflammatory disorders such as neurosar- Neuroimaging characteristics of the lesions were http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Neurologica Belgica Springer Journals

Transient IgG deficiency with lesions in brain and spinal cord: a mimicker of common variable immunodeficiency syndrome

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Publisher
Springer International Publishing
Copyright
Copyright © 2016 by Belgian Neurological Society
Subject
Biomedicine; Neurosciences; Neurology; Neuroradiology; Medicine/Public Health, general
ISSN
0300-9009
eISSN
2240-2993
D.O.I.
10.1007/s13760-016-0722-2
Publisher site
See Article on Publisher Site

Abstract

Acta Neurol Belg (2017) 117:761–763 DOI 10.1007/s13760-016-0722-2 LETTER TO THE EDITOR Transient IgG deficiency with lesions in brain and spinal cord: a mimicker of common variable immunodeficiency syndrome 1 2 3 • • Konark Malhotra Ramnath Santosh Ramanathan Thomas F. Scott Received: 5 September 2016 / Accepted: 5 November 2016 / Published online: 15 November 2016 Belgian Neurological Society 2016 Introduction travel history, skin rash or any tick bites prior to admission. Her neurological exam was negative for bulbar signs, sensory Patients with immune deficiency states often present with abnormalities, sphincter dysfunction or meningismus. MRI- clinical perplexing disease processes, especially involving brain and spine with contrast demonstrated an extensive lesions of the central nervous system (CNS). Common vari- infiltrative process involving basal ganglia, hypothalamus and able immune deficiency (CVID) is a rare primary immune conus medullaris, with enhancing lesions in the upper cervical deficiency disorder that is usually associated with multi-organ cord and conus medullaris (Fig. 1a–c). Our clinical and radi- reversible inflammatory granulomatous lesions, though rarely ological differential diagnosis primarily included lymphoma, present with CNS manifestations. CNS involvement in CVID neurosarcoidosis, and infectious granulomatous diseases. can mimic neuroinflammatory disorders such as neurosar- Neuroimaging characteristics of the lesions were

Journal

Acta Neurologica BelgicaSpringer Journals

Published: Nov 15, 2016

References

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