Transgenic rescue of the tattered phenotype by using a BAC encoding Ebp

Transgenic rescue of the tattered phenotype by using a BAC encoding Ebp Mammalian Genome 12, 323–325 (2001). DOI: 10.1007/s003350010262 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2001 Transgenic rescue of the tattered phenotype by using a BAC encoding Ebp 1 2 1 1 Gary D. Means, Yvonne Boyd, * Cindy R. Willis, Jonathan M.J. Derry Immunex Corporation, 51 University Street, Seattle, Washington 98101, USA MRC Mammalian Genetics Unit, Harwell, Oxon OX11 0RD, UK Received: 7 October 1999 / Accepted: 30 October 2000 Tattered (Td) is an X-linked semi-dominant mouse mutation in which affected males have severe skeletal defects, lack intestines, and die before birth (Uwechue et al. 1996; Derry et al. 1999). Heterozygous females are small and at 4–5 days post partum de- velop patches of hyperkeratotic skin where hair fails to grow (Uwechue et al. 1996). Td/+ females also exhibit mild skeletal defects including craniofacial dysmorphia and asymmetric micro- Fig. 1. A combination of restriction mapping (E 4 EagI, MCS 4 multiple ophthalmia. The phenotype of Td is similar to that seen in patients cloning site) and direct sequencing of BAC75 DNA was used to localize the Ftsjl, DXHXS7465e, and Ebp genes, which are represented schemati- with X-linked dominant chondrodysplasia punctata (CDPX2), cally (arrows indicate the direction of transcription). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

Transgenic rescue of the tattered phenotype by using a BAC encoding Ebp

Loading next page...
 
/lp/springer_journal/transgenic-rescue-of-the-tattered-phenotype-by-using-a-bac-encoding-gR4RCTT83S
Publisher
Springer-Verlag
Copyright
Copyright © 2001 by Springer-Verlag New York Inc.
Subject
Life Sciences; Cell Biology; Anatomy; Zoology
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s003350010262
Publisher site
See Article on Publisher Site

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial