Pharm Res (2018) 35:97 https://doi.org/10.1007/s11095-018-2382-9 RESEARCH PAPER Transferrin-Modified Vitamin-E/Lipid Based Polymeric Micelles for Improved Tumor Targeting and Anticancer Effect of Curcumin 1 1 1 1 Omkara Swami Muddineti & Preeti Kumari & Balaram Ghosh & Swati Biswas Received: 9 November 2017 /Accepted: 4 March 2018 # Springer Science+Business Media, LLC, part of Springer Nature 2018 . . . KEY WORDS active targeting curcumin micelles ABSTRACT Purpose Transferrin receptor (TfR) is up-regulated in various transferrin vitamin E malignant tumors not only to meet the iron requirement, but also to increase the cell survival via participation in various cellular signaling pathways. Here we explored transferrin as ABBREVIATIONS ligand for Poly(ethylene Glycol) (PEG)-ylated vitamin-E/lipid CUR Curcumin (PE) core micelles (VPM). C-VPM Curcumin loaded VPM Methods Transferrin modified polymer was synthesized and DMEM Dulbecco’smodifiedEagle’smedia drug loaded micelles were evaluated in 2D Hela and HepG2 DOPE Dioleoyl phosphatidylethanolamine cancer cells for cellular uptake and cytotoxicity and in 3D Hela FBS Heat-inactivated fetal bovine serum spheroids for growth inhibition, uptake and penetration studies. FC Free curcumin Results Targeted (Tf-VPM) and non-targeted (VPM) mi- h Hour celles showed mean hydrodynamic diameter of 114.2 ± Hela Human cervical carcinoma cells 0.64 nm and 117.4 ± 0.72 nm
Pharmaceutical Research – Springer Journals
Published: Mar 14, 2018
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