Transcriptomic microarray analysis of BoMac cells after infection with bovine foamy virus

Transcriptomic microarray analysis of BoMac cells after infection with bovine foamy virus Bovine foamy virus (BFV) infections are highly prevalent among cattle worldwide. However, relatively little is known about the impact of this virus on the host immune system. In our study, we focused on a bovine macrophage cell line (BoMac) and examined changes in the BoMac transcriptome after in vitro infection with BFV using bovine BLOPlus oligo microarrays. One hundred twenty-four genes showed significant changes in expression level. The biological process categories found to be enriched include metabolic processes, cell communication, transport, immune system processes, and response to extracellular stimuli. RT-qPCR was applied to confirm the results obtained for representative genes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Transcriptomic microarray analysis of BoMac cells after infection with bovine foamy virus

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Publisher
Springer Vienna
Copyright
Copyright © 2014 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-013-1959-1
Publisher site
See Article on Publisher Site

Abstract

Bovine foamy virus (BFV) infections are highly prevalent among cattle worldwide. However, relatively little is known about the impact of this virus on the host immune system. In our study, we focused on a bovine macrophage cell line (BoMac) and examined changes in the BoMac transcriptome after in vitro infection with BFV using bovine BLOPlus oligo microarrays. One hundred twenty-four genes showed significant changes in expression level. The biological process categories found to be enriched include metabolic processes, cell communication, transport, immune system processes, and response to extracellular stimuli. RT-qPCR was applied to confirm the results obtained for representative genes.

Journal

Archives of VirologySpringer Journals

Published: Jun 1, 2014

References

  • Use of within-array replicate spots for assessing differential expression in microarray experiments
    Smyth, GK; Michaud, J; Scott, HS
  • Effects of heat shock protein gp96 on human dendritic cell maturation and CTL expansion
    Zhang, Y; Zan, Y; Shan, M; Liu, C; Shi, M; Li, W; Zhang, Z; Liu, N; Wang, F; Zhong, W; Liao, F; Gao, GF; Tien, P
  • Human foamy virus bel1 sequence in patients with autoimmune rheumatic diseases
    Sun, KH; Lin, HY; Chen, LW; Tai, HY; Lin, ML; Feng, CK; Sung, JS; Liu, HF; Liu, WT
  • The Influence of HLA Genotype on AIDS
    Carrington, M; O’Brien, SJ
  • Identification and characterization of taxilin isoforms
    Nogami, S; Satoh, S; Tanaka-Nakadate, S; Yoshida, K; Nakano, M; Terano, A; Shirataki, H

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