Transcriptional gene silencing mutants

Transcriptional gene silencing mutants Genetic approaches to identify molecular components of transcriptional gene silencing (TGS) in plants have yielded several Arabidopsis thaliana mutants and identified the first genes involved. All mutations found affect the maintenance of silencing and reactivate silent genes in trans. The mutations fall into two categories: ddm1 and hog release silencing in association with decreased levels of DNA methylation, while sil and mom reactivate genes without changing the methylation state. While plants homozygous over several generations for hog, sil or mom exhibit no morphological changes, ddm1-type mutants accumulate developmental abnormalities. The mutants indicate that TGS in plants is controlled by several genetic components and possibly by multiple independent pathways. The DDM1 gene was assigned to the SWI2/SNF2 gene family of chromatin-remodelling proteins, the MOM gene is a novel protein and the other loci have not yet been characterized. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Plant Molecular Biology Springer Journals

Transcriptional gene silencing mutants

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Publisher
Springer Journals
Copyright
Copyright © 2000 by Kluwer Academic Publishers
Subject
Life Sciences; Biochemistry, general; Plant Sciences; Plant Pathology
ISSN
0167-4412
eISSN
1573-5028
D.O.I.
10.1023/A:1006487529698
Publisher site
See Article on Publisher Site

Abstract

Genetic approaches to identify molecular components of transcriptional gene silencing (TGS) in plants have yielded several Arabidopsis thaliana mutants and identified the first genes involved. All mutations found affect the maintenance of silencing and reactivate silent genes in trans. The mutations fall into two categories: ddm1 and hog release silencing in association with decreased levels of DNA methylation, while sil and mom reactivate genes without changing the methylation state. While plants homozygous over several generations for hog, sil or mom exhibit no morphological changes, ddm1-type mutants accumulate developmental abnormalities. The mutants indicate that TGS in plants is controlled by several genetic components and possibly by multiple independent pathways. The DDM1 gene was assigned to the SWI2/SNF2 gene family of chromatin-remodelling proteins, the MOM gene is a novel protein and the other loci have not yet been characterized.

Journal

Plant Molecular BiologySpringer Journals

Published: Oct 16, 2004

References

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