Reactions 1680, p326 - 2 Dec 2017 Elevation in prothrombin time and international normalised ratio: case report In a study of 54 patients, a patient was described, who developed elevation of prothrombin time and international normalised ratio (PT-INR) following co-administration of warfarin and tramadol tablets [age, sex, dosages, routes, time to reaction onset and outcome not stated]. Decreased liver function was also observed after tramadol co-administration. The patient required reduction in warfarin dose due to elevation of PT-INR. Author comment: "There was one patient among the cases eligible for the study who had a clear care of decreased liver function who was included in the elevated group." "Co- administration of [warfarin] and [tramadol] caused a significant elevation in PT-INR". Hosono T, et al. Effects of Tramadol Coadministration on Prothrombin Time- International Normalized Ratio in Patients Receiving Warfarin. Yakugaku Zasshi 137: 999-1003, No. 8, 2017. Available from: URL: http://doi.org/10.1248/ yakushi.16-00270 [Japanese; summarised from a translation] - Japan 803284310 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680
Reactions Weekly – Springer Journals
Published: Dec 2, 2017
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