Toxicity interactions between manganese (Mn) and lead (Pb) or cadmium (Cd) in a model organism the nematode C. elegans

Toxicity interactions between manganese (Mn) and lead (Pb) or cadmium (Cd) in a model organism... Manganese (Mn) is considered as an emerging metal contaminant in the environment. However, its potential interactions with companying toxic metals and the associated mixture effects are largely unknown. Here, we investigated the toxicity interactions between Mn and two commonly seen co-occurring toxic metals, Pb and Cd, in a model organism the nematode Caenorhabditis elegans. The acute lethal toxicity of mixtures of Mn+Pb and Mn+Cd were first assessed using a toxic unit model. Multiple toxicity endpoints including reproduction, lifespan, stress response, and neurotoxicity were then examined to evaluate the mixture effects at sublethal concentrations. Stress response was assessed using a daf-16::GFP transgenic strain that expresses GFP under the control of DAF-16 promotor. Neurotoxicity was assessed using a dat-1::GFP transgenic strain that expresses GFP in dopaminergic neurons. The mixture of Mn+Pb induced a more-than-additive (synergistic) lethal toxicity in the worm whereas the mixture of Mn+Cd induced a less-than-additive (antagonistic) toxicity. Mixture effects on sublethal toxicity showed more complex patterns and were dependent on the toxicity endpoints as well as the modes of toxic action of the metals. The mixture of Mn+Pb induced additive effects on both reproduction and lifespan, whereas the mixture of Mn+Cd induced additive effects on lifespan but not reproduction. Both mixtures seemed to induce additive effects on stress response and neurotoxicity, although a quantitative assessment was not possible due to the single concentrations used in mixture tests. Our findings demonstrate the complexity of metal interactions and the associated mixture effects. Assessment of metal mixture toxicity should take into consideration the unique property of individual metals, their potential toxicity mechanisms, and the toxicity endpoints examined. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Environmental Science and Pollution Research Springer Journals

Toxicity interactions between manganese (Mn) and lead (Pb) or cadmium (Cd) in a model organism the nematode C. elegans

12 pages
Read Article

Loading next page...
 
/lp/springer_journal/toxicity-interactions-between-manganese-mn-and-lead-pb-or-cadmium-cd-7avnEc0Nb5
Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer-Verlag GmbH Germany, part of Springer Nature
Subject
Environment; Environment, general; Environmental Chemistry; Ecotoxicology; Environmental Health; Atmospheric Protection/Air Quality Control/Air Pollution; Waste Water Technology / Water Pollution Control / Water Management / Aquatic Pollution
ISSN
0944-1344
eISSN
1614-7499
D.O.I.
10.1007/s11356-018-1752-5
Publisher site
See Article on Publisher Site

Abstract

Manganese (Mn) is considered as an emerging metal contaminant in the environment. However, its potential interactions with companying toxic metals and the associated mixture effects are largely unknown. Here, we investigated the toxicity interactions between Mn and two commonly seen co-occurring toxic metals, Pb and Cd, in a model organism the nematode Caenorhabditis elegans. The acute lethal toxicity of mixtures of Mn+Pb and Mn+Cd were first assessed using a toxic unit model. Multiple toxicity endpoints including reproduction, lifespan, stress response, and neurotoxicity were then examined to evaluate the mixture effects at sublethal concentrations. Stress response was assessed using a daf-16::GFP transgenic strain that expresses GFP under the control of DAF-16 promotor. Neurotoxicity was assessed using a dat-1::GFP transgenic strain that expresses GFP in dopaminergic neurons. The mixture of Mn+Pb induced a more-than-additive (synergistic) lethal toxicity in the worm whereas the mixture of Mn+Cd induced a less-than-additive (antagonistic) toxicity. Mixture effects on sublethal toxicity showed more complex patterns and were dependent on the toxicity endpoints as well as the modes of toxic action of the metals. The mixture of Mn+Pb induced additive effects on both reproduction and lifespan, whereas the mixture of Mn+Cd induced additive effects on lifespan but not reproduction. Both mixtures seemed to induce additive effects on stress response and neurotoxicity, although a quantitative assessment was not possible due to the single concentrations used in mixture tests. Our findings demonstrate the complexity of metal interactions and the associated mixture effects. Assessment of metal mixture toxicity should take into consideration the unique property of individual metals, their potential toxicity mechanisms, and the toxicity endpoints examined.

Journal

Environmental Science and Pollution Research – Springer Journals

Published: Mar 21, 2018

References

  • Dopamine selectively sensitizes dopaminergic neurons to rotenone-induced apoptosis
    Ahmadi, FA; Grammatopoulos, TN; Poczobutt, AM; Jones, SM; Snell, LD; Das, M
  • Manganese: recent advances in understanding its transport and neurotoxicity
    Aschner, M; Guilarte, TR; Schneider, JS; Zheng, W
  • A comparative study of genotype sensitivity to acute toxic stress using clones of Daphnia magna Straus
    Baird, DJ; Barber, I; Bradley, M; Soares, AMVM; Calow, P
  • Endocrine signaling in Caenorhabditis elegans controls stress response and longevity
    Baumeister, R; Schaffitzel, E; Hertweck, M
  • Extracellular dopamine potentiates Mn-induced oxidative stress, lifespan reduction, and dopaminergic neurodegeneration in a BLI-3-dependent manner in Caenorhabditis elegans
    Benedetto, A; Au, C; Avila, DS; Milatovic, D; Aschner, M
  • Hair manganese and hyperactive behaviors: pilot study of school-age children exposed through tap water
    Bouchard, M; Laforest, F; Vandelac, L; Bellinger, D; Mergler, D
  • Aquatic toxicology and risk assessment, Vol. 14. STP 1124. American Society for TESTING AND materials, Philadephia, PA
    Broderius, SJ
  • Manganese neurotoxicity: lessons learned from longitudinal studies in nonhuman primates
    Burton, NC; Guilarte, TR
  • Quantifying synergy: a systematic review of mixture toxicity studies within environmental toxicology
    Cedergreen, N
  • The diagnosis of manganese-induced parkinsonism
    Cersosimo, MG; Koller, WC
  • Age- and manganese-dependent modulation of dopaminergic phenotypes in a C. elegans DJ-1 genetic model of Parkinson’s disease
    Chen, P; DeWitt, MR; Bornhorst, J; Soares, FA; Mukhopadhyay, S; Bowman, AB
  • Toxicity of copper, lead, and zinc mixtures to Ceriodaphnia dubia and Daphnia carinata
    Cooper, NL; Joseph, RB; Kumar, A
  • Cadmium stress: an oxidative challenge
    Cuypers, A; Plusquin, M; Remans, T; Jozefczak, M; Keunen, E; Gielen, H; Opdenakker, K; Nair, AR; Munters, E; Artois, TJ; Nawrot, T; Vangronsveld, J; Smeets, K
  • Toxicity of lead: a review with recent updates
    Flora, G; Deepesh, G; Tiwari, AR
  • Dmt1: a mammalian transporter for multiple metals
    Garrick, MD; Dolan, KG; Horbinski, C; Ghio, AJ; Higgins, D; Porubcin, M
  • Speciation of manganese in cells and mitochondria: a search for the proximal cause of manganese neurotoxicity
    Gunter, TE; Gavin, CE; Aschner, M; Gunter, KK
  • Role of MTL-1, MTL-2, and CDR-1 in mediating cadmium sensitivity in Caenorhabditis elegans
    Hall, J; Haas, KL; Freedman, JH
  • Manganese toxicity to tropical freshwater species in low hardness water
    Harford, AJ; Mooney, TJ; Trenfield, MA; Dam, RA
  • Central nervous system toxicity of manganese. II: cocaine or reserpine inhibit manganese concentration in the rat brain
    Ingersoll, RT; Montgomery, EB; Aposhian, HV
  • The chronic toxicity of manganese to the amphipod crustacean Hyalella Azteca using a standardized flow-through experiment
  • Significance testing of synergistic/antagonistic, dose level-dependent, or dose ratio-dependent effects in mixture dose-response analysis
    Jonker, MJ; Svendsen, C; Bedaux, JJM; Bongers, M; Kammenga, JE
  • Preweaning mn exposure leads to prolonged astrocyte activation and lasting effects on the dopaminergic system in adult male rats
    Kern, CH; Smith, DR
  • Manganese exposure from drinking water and children's classroom behavior in Bangladesh
    Khan, K; Factor-Litvak, P; Wasserman, GA; Liu, X; Ahmed, E; Parvez, F
  • Ecotoxicity of mixtures of metals to the zebra mussel Dreissena polymorpha
    Kraak, MHS; Lavy, D; Schoon, H; Toussaint, M; Peeters, WHM; Straalen, NM
  • Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology
    Leung, MC; Williams, PL; Benedetto, A; Au, C; Helmcke, KJ; Aschner, M; Meyer, JN
  • Heavy metal contamination in soils and phytoaccumulation in a manganese mine wasteland, South China
    Li, MS; Yang, SX
  • Occupational health services in PR China
    Liang, Y; Xiang, Q
  • A transgenic strain of the nematode C. elegans as a biomonitor for heavy metal contamination
    Ma, H; Glenn, TC; Jagoe, CH; Jones, KL; Williams, PL
  • Fundamentals of aquatic toxicology: methods and applications
    Marking, LL
  • Oxidative damage and neurodegeneration in manganese-induced neurotoxicity
    Milatovic, D; Zaja-Milatovic, S; Gupta, RC; Yu, Y; Aschner, M
  • Mechanisms of lead and manganese neurotoxicity
    Neal, AP; Guilarte, TR
  • Manganese toxicity upon overexposure: a decade in review
  • The fork head transcription factor daf-16 transduces insulin-like metabolic and longevity signals in C. elegans
    Ogg, S; Paradis, S; Gottlieb, S; Patterson, GI; Lee, L; Tissenbaum, HA
  • The role of metal ions in dopaminergic neuron degeneration in parkinsonism and parkinson’s disease
    Paris, I; Segura-Aguilar, J
  • Environmental Contamination
    Pinsino, A; Matranga, V; Carmela Roccheri, M
  • Single and joint toxic effects of copper and zinc on reproduction of Enchytraeus crypticusin relation to sorption of metals in soils
    Posthuma, L; Baerselman, R; Veen, RP; Dirven-Van, BEM
  • Characterization of developmental neurotoxicity of As, Cd, and Pb mixture: synergistic action of metal mixture in glial and neuronal functions
    Rai, A; Maurya, SK; Khare, P; Srivastava, A; Bandyopadhyay, S
  • Assessment of stress-related gene expression in the heavy metal-exposed nematode Caenorhabditis elegans: a potential biomarker for metal-induced toxicity monitoring and environmental risk assessment
    Roh, JY; Lee, J; Choi, J
  • C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway
    Sawin, ER; Ranganathan, R; Horvitz, HR
  • The divalent metal transporter homologues SMF-1/2 mediate dopamine neuron sensitivity in caenorhabditis elegans models of manganism and Parkinson disease
    Settivari, R; Levora, J; Nass, R
  • The Nrf2/SKN-1-dependent glutathione S-transferase pi homologue GST-1 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of manganism
    Settivari, R; VanDuyn, N; LeVora, J; Nass, R
  • Control of Cd concentrations in a coastal diatom by interactions among free ionic Cd, Zn, and Mn in seawater
    Sunda, WG; Huntsman, SA
  • Interactive effects of external manganese, the toxic metals copper and zinc, and light in controlling cellular manganese and growth in a coastal diatom
    Sunda, WG; Huntsman, SA
  • Cadmium: toxic effects on the reproductive system and the embryo
    Thompson, J; Bannigan, J
  • Toxicity of metals and metal mixtures: analysis of concentration and time dependence for zinc and copper
    Utgikar, VP; Chaudhary, N; Koeniger, A; Tabak, HH; Haines, JR; Govind, R
  • Interaction of Cd and Zn toxicity for Folsomia candida Willem (Collembola: Isotomidae) in relation to bioavailability in soil
    Gestel, CAM; Paul, JH
  • Metal toxicology
    Verity, MA
  • Response predictions for organisms water-exposed to metal mixtures: a meta-analysis
    Vijver, MG; Elliott, EG; Peijenbury, WJ; Snoo, GR
  • Synergistic toxicity of multiple heavy metals is revealed by a biological assay using a nematode and its transgenic derivative
    Wah Chu, K; Chow, KL
  • 1160 welders’ health condition analysis
    Wang, X
  • Mixture toxicity and tissue interactions of Cd, Cu, Pb and Zn in earthworms (Oligochaeta) in laboratory and field soils: a critical evaluation of data
    Weltje, L
  • Aquatic toxicity testing using the nematode, Caenorhabditis elegans
    Williams, PL; Dusenbery, DB

You’re reading a free preview. Subscribe to read the entire article.

Try 2 weeks free now

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

or browse the journals available

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off

Sign up
for free
Start 14 day
Free Trial