Topogenic Motifs in P-type ATPases

Topogenic Motifs in P-type ATPases J. Membrane Biol. 174, 181–190 (2000) The Journal of Membrane Biology © Springer-Verlag New York Inc. 2000 Topical Review K. Geering Institut de Pharmacologie et Toxicologie, Universite ´ de Lausanne, rue du Bugnon 27, CH-1005 Lausanne, Switzerland Received: 1 December 1999 Introduction port, is not known. Comparison of hydropathy profiles suggests that the membrane topology of P-type ATPases P-type ATPases comprise a superfamily of ubiquitous correlates with the type of ion transported. This has led pumps that are involved in the transport of charged sub- to the distinction of P1-ATPases (heavy metal pumps) + + strates across biological membranes including K ,Na , and P2-ATPases (nonheavy metal pumps and phospho- + 2+ 2+ 2+ 2+ 2+ H ,Ca ,Mg ,Cu ,Cd ,Zn and phospholipids. lipid translocases) with very distinct hydropathy profiles Most of these P-type ATPases function with a single and P3-ATPases (bacterial K-pumps) which share struc- subunit but some are two or multi-subunit complexes. tural features with both P1- and P2-ATPases (Lutsenko Transport of substrates involves at least two conforma- & Kaplan, 1995). A more stringent analysis including tional states E1 and E2 and is driven by the energy of the sequence comparison and alignment of conserved core The Journal of Membrane Biology Springer Journals

Topogenic Motifs in P-type ATPases

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Copyright © Inc. by 2000 Springer-Verlag New York
Life Sciences; Biochemistry, general; Human Physiology
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