J. Membrane Biol. 174, 181–190 (2000) The Journal of Membrane Biology © Springer-Verlag New York Inc. 2000 Topical Review K. Geering Institut de Pharmacologie et Toxicologie, Universite ´ de Lausanne, rue du Bugnon 27, CH-1005 Lausanne, Switzerland Received: 1 December 1999 Introduction port, is not known. Comparison of hydropathy profiles suggests that the membrane topology of P-type ATPases P-type ATPases comprise a superfamily of ubiquitous correlates with the type of ion transported. This has led pumps that are involved in the transport of charged sub- to the distinction of P1-ATPases (heavy metal pumps) + + strates across biological membranes including K ,Na , and P2-ATPases (nonheavy metal pumps and phospho- + 2+ 2+ 2+ 2+ 2+ H ,Ca ,Mg ,Cu ,Cd ,Zn and phospholipids. lipid translocases) with very distinct hydropathy profiles Most of these P-type ATPases function with a single and P3-ATPases (bacterial K-pumps) which share struc- subunit but some are two or multi-subunit complexes. tural features with both P1- and P2-ATPases (Lutsenko Transport of substrates involves at least two conforma- & Kaplan, 1995). A more stringent analysis including tional states E1 and E2 and is driven by the energy of the sequence comparison and alignment of conserved core
The Journal of Membrane Biology – Springer Journals
Published: Apr 1, 2000
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