Background Anal ﬁssure is a common anorectal problem causing severe pain and discomfort to the patients. Chemical sphincterotomy has emerged as a noninvasive alternative to the surgical methods of ﬁssure treatment. The objective of this study was evaluation of the efﬁcacy and the adverse effects of topically applied minoxidil in chemical sphincterotomy of chronic anal ﬁssure in comparison with topical diltiazem. Methods A total of 88 patients with chronic anal ﬁssure aged between 15 and 65 years were included in this double- blind, randomized clinical trial and were randomly assigned to either 0.5% minoxidil cream or 2% diltiazem cream twice daily for 2 weeks. The pain intensity, bleeding, wound healing, itching, headache, dizziness, signiﬁcant drop in blood pressure, allergy and ﬁssure relapse were assessed on a monthly basis for 2 months. Results Both diltiazem and minoxidil reduced the pain, bleeding and improved ﬁssure healing with no signiﬁcant difference. There were no between-groups differences in the frequencies of adverse effects, except for itching which was slightly higher with minoxidil during the ﬁrst month. Allergy occurred in two patients in the minoxidil group, which was not severe and did not lead to discontinuation of the trial. Conclusion Topically administered minoxidil is
World Journal of Surgery – Springer Journals
Published: Dec 31, 2017
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