Tolvaptan Reactions 1680, p325 - 2 Dec 2017 Liver dysfunction and cerebral infarction: 2 case reports In a retrospective, observational study of 21 patients, two patients [ages and sexes not stated] were described who developed liver dysfunction and cerebral infarction, respectively during therapy with tolvaptan [route and dosage not stated]. The patients with chronic kidney disease and congestive heart failure, received tolvaptan for excess body fluid. However, one patient developed liver dysfunction while another patient developed cerebral infarction during therapy with tolvaptan. Subsequently, tolvaptan was discontinued in both patients [durations of treatment to reactions onset and outcomes not stated]. Author comment: "Two cases were not able to continue use of tolvaptan because of its side effects". "Among 21 study participants, 2 patients discontinued tolvaptan treatment during the study periods because of liver dysfunction and cerebral infarction, respectively." Katsumata M, et al. Effects of tolvaptan in patients with chronic kidney disease and chronic heart failure. Clinical and Experimental Nephrology 21: 858-865, No. 5, Oct 2017. Available from: URL: - Japan 803283918 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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