Originalien 1 1 1 1 2 Z Rheumatol 2018 · 77:416–420 I. I. Raafat ·N.El Guindy ·R. M.H. Shahin ·L.A. Samy ·R.M.El Refai https://doi.org/10.1007/s00393-017-0283-7 Department of Clinical Pathology, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt Published online: 27 February 2017 Department of Rheumatology and Rehabilitation, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt © Springer-Verlag Berlin Heidelberg 2017 Redaktion U. Müller-Ladner, Bad Nauheim Toll-like receptor 7 gene single U. Lange, Bad Nauheim nucleotide polymorphisms and the risk for systemic lupus erythematosus: a case-control study of type I interferon (type I IFN), a cardi- croRNA-3148 (miR-3148) resulting in Introduction nal cytokine in the pathogenesis of SLE a faster breakdown of the transcript and Systemic lupus erythematosus (SLE) is . thus lower levels of TLR7 gene product a polygenic disease that is aﬀected by eth- Up-regulated TLR7 mRNA expres- . nicity, gender, andenvironmentalfactors. sion has been detected in peripheral Within this context, this case–control Toll-likereceptor7(TLR7)hasbeenthor- blood mononuclear cells (PBMCs) from study was carried out to detect whether oughly studied using lupus-prone mouse SLE patients and levels correlate with TLR7 rs3853839 and rs179019 SNPs con- models . the expression of type I IFNs, including fer risk to SLE in a cohort
Zeitschrift für Rheumatologie – Springer Journals
Published: Feb 27, 2017
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