Adv Ther (2018) 35:749–753 https://doi.org/10.1007/s12325-018-0719-8 COMMENTARY To See or NOsee: The Debate on the Nocebo Effect and Optimizing the Use of Biosimilars Mourad F. Rezk Burkhard Pieper Received: April 16, 2018 / Published online: June 5, 2018 Springer Healthcare Ltd., part of Springer Nature 2018 Abstract: In addition to the general clinical clinical trials, and that this effect may nega- beneﬁt offered, biosimilars may not only gen- tively affect acceptance in patients switching erate savings for healthcare budgets but also from an originator product to a biosimilar. improve patient access to biologic products. Awareness of the potential for the nocebo effect Since the ﬁrst biosimilar was approved in Eur- and adoption of enhanced communication ope in 2006, a further 36 different biosimilar techniques may be useful in mitigating the drugs have been approved for several indica- nocebo effect. Effective healthcare profes- tions. Despite the wealth of experience gained sional–patient dialogue is key in transferring and the reported data supporting the use of conﬁdence to the patient, and has been shown biosimilars, both in naı¨ve and biologic-experi- to reduce nocebo effects in patients when enced patients, some healthcare professionals switching from an originator to a biosimilar. continue to express doubt
Advances in Therapy – Springer Journals
Published: Jun 5, 2018
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