Russian Journal of Developmental Biology, Vol. 33, No. 5, 2002, pp. 322–323. Translated from Ontogenez, Vol. 33, No. 5, 2002, pp. 393–394. Original Russian Text Copyright © 2002 by Korochkin. JUBILEES After several preliminary studies (1935), Lopashov tried to follow a nascent molecular biology. This in view, he tried to answer the question whether the “killed” (by alcohol) eye rudiments were able to release substances that induced the eyes, rather than lenses. He answered this question positively (1936) but could not go further and isolate the inducing substances. These experiments served as a basis for studying the role of factors released by the eye cells in their own dif- ferentiation. It was shown that the pure pigment epithe- lium of tadpoles and adult frogs in the posterior cavity of their eyes, like in the retina clefts, transformed into retina (Lopashov, 1949; Lopashov and Sologub, 1972). However, this could be due to the stimulation of prolif- eration of the pigment epithelium cells. But it was shown in further experiments that the pigment epithe- lium covered by the lens epithelium differentiated into lentoids or retina with respect to whether these com- plexes were cultivated in a protein-free medium or transplanted at
Russian Journal of Developmental Biology – Springer Journals
Published: Oct 13, 2004
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