1062-3604/02/3305- $27.00 © 2002
Russian Journal of Developmental Biology, Vol. 33, No. 5, 2002, pp. 320–321. Translated from Ontogenez, Vol. 33, No. 5, 2002, pp. 391–392.
Original Russian Text Copyright © 2002 by Korochkin, Vassetzky.
On April 18, 2002, Andrei Pavlovich Dyban was
80 years old. He is an outstanding Russian embryolo-
gist, a scientist with world recognition, who made a
great contribution to the developmental biology of
mammals. A.P. Dyban is Doctor of medical sciences
(1960), professor (1960), Honoured Scientist of the
Russian Federation (1998), Doctor honoris causa of the
Research Institute of Experimental medicine, Russian
Academy of medical Sciences (2000).
Dyban was born in 1922 in Uman’, Kiev
(Cherkassy) District, in the family of physicians. His
parents are well known clinicians (father ophthalmolo-
gist, candidate of medical sciences, and mother phthis-
iologist), who made a lot for the development of health
science in Ukraine.
In 1939, Dyban entered the Kiev Medical Institute,
from which he graduated in Chelyabinsk in 1944. In
1944–1947, he worked as an assistant at the Depart-
ment of Histology and Embryology and graduated from
the postgraduate School at the Kiev Medical Institute.
In 1947, Dyban got his candidate degree (PhD) for the
Gistologicheskie struktury anomal’nykh zarody-
(Histological Structures of Abnormal
Human Embryos) and was sent to the L’vov Medical
Institute by the Ministry of Health of Ukraine. In 1960,
he got a doctoral degree for his monograph (Dyban,
1959) at the Institute of Experimental Medicine in Len-
In 1947–1963, Dyban headed the Department of
Histology and Embryology at the L’vov Medical Insti-
tute, where he was held in esteem and love of students
and professors. In 1963–1991, he headed the Depart-
ment of Embryology, at the Institute of Experimental
medicine, Russian Academy of Sciences, in Leningrad.
In 1991–1995, he was on a leave in the USA and, since
1995, he is working at the Department of Molecular
Genetics, Institute of Experimental Medicine.
A.P. Dyban is the author of 240 publications, includ-
ing 214 papers in Russian and international journals,
19 chapters in books or collective monographs, and six
monographs, three of which were published abroad
(Dyban, 1962, 1990; Dyban and Baranov, 1987).
Dyban mad a considerable contribution to experi-
mental teratology of mammals. After the thalidomide
tragedy, a group of WHO experts, including
A.P. Dyban, elaborated the main principles of testing
the teratogenicity and embryotoxicity of medicinal
drugs (1968). Later, A.P. Dyban and his coworkers
established the main patterns of the damaging effect of
various alterating agents at different stages of mamma-
lian development. These data constituted the basis of
more complete rules of preclinical testing of medicinal
drugs for teratogenicity and embryotoxicity, which
were passed by the USSR Ministry of Health (1972,
1986) and introduced into health service.
Dyban and his coworkers carried out a large cycle of
studies on goal-directed effects on oogenesis and early
embryogenesis in mammals. New methods were elabo-
rated fro artiﬁcial activation of eggs and the behavior of
chromosome during experimental parthenogenesis was
studied in detail.
The works of A.P. Dyban on experimental cytoge-
netics of mammalian development are well known both
in our country and abroad. He developed a new tech-
nique of chromosomal analysis of the early mammalian
embryos, which allowed him and his coworkers to ana-
lyze in detail the inﬂuence of numerical and structural
chromosome aberrations on the key links of embryo-
genesis. Dyban formulated new concepts on the role of
different chromosomes in early development and com-
bined participation of genes and epigenomic factors in
the controlling mechanisms of early mammalian devel-
Together with the Laboratory of Behavioral Genet-
ics, Department of Higher Nervous Activity of the
Moscow State University, Dyban and his coworkers
To 80th Birthday of Andrei Pavlovich Dyban