Purpose Exposure to hypoxia has been suggested to activate multiple adaptive pathways so that muscles are better able to maintain cellular energy homeostasis. However, there is limited research regarding the tissue specificity of this response. The aim of this study was to investigate the influence of tissue specificity on mitochondrial adaptations of rat skeletal and heart muscles after 4 weeks of normobaric hypoxia (FiO : 0.10). Methods Twenty male Wistar rats were randomly assigned to either normobaric hypoxia or normoxia. Mitochondrial respiration was determined in permeabilised muscle fibres from left and right ventricles, soleus and extensorum digitorum longus (EDL). Citrate synthase activity and the relative abundance of proteins associated with mitochondrial biogenesis were also analysed. Results After hypoxia exposure, only the soleus and left ventricle (both predominantly oxidative) presented a greater maximal + + + + mass-specific respiration ( 48 and 25%, p < 0.05) and mitochondrial-specific respiration ( 75 and 28%, p < 0.05). Citrate − 1 − 1 synthase activity was higher in the EDL (0.63 ± 0.08 vs 0.41 ± 0.10 µmol min µg ) and lower in the soleus (0.65 ± 0.17 − 1 − 1 vs 0.87 ± 0.20 µmol min µg ) in hypoxia with respect
European Journal of Applied Physiology – Springer Journals
Published: May 31, 2018
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