Tissue engineering of bone in muscle by using free periosteal grafts with a self-reinforced polyglycolide membrane scaffold. An experimental study in growing rabbits

Tissue engineering of bone in muscle by using free periosteal grafts with a self-reinforced... For tissue engineering of predesigned rectangular bone from free tibial and calvarial periosteal grafts, using self-reinforced polyglycolide membrane (SR-PGA) as a scaffold, fourteen growing New Zealand White rabbits were used. In twelve animals, free tibial and calvarial periosteal grafts wrapped around membranes and grafts without membranes were implanted in muscle. In two control animals membranes only were implanted. Follow-up periods were 6 and 12 weeks. Bone formation and tissue reactions were evaluated macroscopically and histologically. Tibial grafts produced bone more often than calvarial grafts (11/12 vs. 5/12). At 6 weeks mature rectangular bone was obtained from tibial grafts with membranes, whereas none was obtained from calvarial grafts with membranes. At 12 weeks, bone ossicles obtained from both types of graft with membranes were clearly smaller than at 6 weeks and the rectangular form was lost. SR-PGA membrane can be used as a scaffold to obtain predesigned rectangular bone from free tibial periosteal grafts in growing rabbits. Transplantation should be performed before resorption occurs. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Plastic Surgery Springer Journals

Tissue engineering of bone in muscle by using free periosteal grafts with a self-reinforced polyglycolide membrane scaffold. An experimental study in growing rabbits

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Publisher
Springer Journals
Copyright
Copyright © 2000 by Springer-Verlag Berlin Heidelberg
Subject
Medicine & Public Health; Plastic Surgery
ISSN
0930-343X
eISSN
1435-0130
D.O.I.
10.1007/s002380050010
Publisher site
See Article on Publisher Site

Abstract

For tissue engineering of predesigned rectangular bone from free tibial and calvarial periosteal grafts, using self-reinforced polyglycolide membrane (SR-PGA) as a scaffold, fourteen growing New Zealand White rabbits were used. In twelve animals, free tibial and calvarial periosteal grafts wrapped around membranes and grafts without membranes were implanted in muscle. In two control animals membranes only were implanted. Follow-up periods were 6 and 12 weeks. Bone formation and tissue reactions were evaluated macroscopically and histologically. Tibial grafts produced bone more often than calvarial grafts (11/12 vs. 5/12). At 6 weeks mature rectangular bone was obtained from tibial grafts with membranes, whereas none was obtained from calvarial grafts with membranes. At 12 weeks, bone ossicles obtained from both types of graft with membranes were clearly smaller than at 6 weeks and the rectangular form was lost. SR-PGA membrane can be used as a scaffold to obtain predesigned rectangular bone from free tibial periosteal grafts in growing rabbits. Transplantation should be performed before resorption occurs.

Journal

European Journal of Plastic SurgerySpringer Journals

Published: Jan 14, 2000

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