Access the full text.
Sign up today, get DeepDyve free for 14 days.
M. Friedman, C. Levin (1995)
.alpha.-Tomatine Content in Tomato and Tomato Products Determined by HPLC with Pulsed Amperometric DetectionJournal of Agricultural and Food Chemistry, 43
K. Bouarab, R. Melton, Jack Peart, D. Baulcombe, A. Osbourn (2002)
A saponin-detoxifying enzyme mediates suppression of plant defencesNature, 418
A. Saxena, Donald Maxwell, Daniel Quinn, Z. Radić, Palmer Taylor, B. Doctor (1997)
Mutant acetylcholinesterases as potential detoxification agents for organophosphate poisoning.Biochemical pharmacology, 54 2
C. McTiernan, S. Adkins, A. Chatonnet, T. Vaughan, C. Bartels, M. Kott, T. Rosenberry, B. Du, O. Lockridge (1987)
Brain cDNA clone for human cholinesterase.Proceedings of the National Academy of Sciences of the United States of America, 84 19
H.M. Lam, J. Chiu, M.H. Hsieh, L. Meisel, I.C. Oliveira, M. Shin, G. Coruzzi (1998)
Glutamate-receptor genes in plants [letter]Nature, 396
J.G. Roddick (1996)
Saponins Used in Traditional and Modern Medicine
Peter Henriksen, Wayne Carmichael, J. An, Ø. Moestrup (1997)
Detection of an anatoxin-a(s)-like anticholinesterase in natural blooms and cultures of cyanobacteria/blue-green algae from Danish lakes and in the stomach contents of poisoned birds.Toxicon : official journal of the International Society on Toxinology, 35 6
T.S. Mor, M. Sternfeld, H. Soreq, C.J. Arntzen, H.S. Mason (2001)
Expression of recombinant human acetylcholinesterase in transgenic tomato plantsBiotechnol. Bioeng., 75
J. Roddick (1974)
The steroidal glycoalkaloid α-tomatinePhytochemistry, 13
I. Mendelson, C. Kronman, N. Ariel, A. Shafferman, B. Velan (1998)
Bovine acetylcholinesterase: cloning, expression and characterization.The Biochemical journal, 334 ( Pt 1)
M. Friedman (2002)
Tomato glycoalkaloids: role in the plant and in the diet.Journal of agricultural and food chemistry, 50 21
H. Lam, J. Chiu, M. Hsieh, L. Meisel, I. Oliveira, M. Shin, G. Coruzzi (1998)
Glutamate-receptor genes in plantsNature, 396
C. Hall (1994)
Prospects for a respiratory syncytial virus vaccine.Science, 265 5177
Y. Jia, Y. Loh, J. Zhou, G. Martin (1997)
Alleles of Pto and Fen occur in bacterial speck-susceptible and fenthion-insensitive tomato cultivars and encode active protein kinases.The Plant cell, 9
J. Riov, M. Jaffe (1973)
Cholinesterases from plant tissues: I. Purification and characterization of a cholinesterase from mung bean roots.Plant physiology, 51 3
H. Mason, H. Warzecha, T. Mor, C. Arntzen (2002)
Edible plant vaccines: applications for prophylactic and therapeutic molecular medicine.Trends in molecular medicine, 8 7
J. Massoulie, A. Anselmet, S. Bon, E. Krejci, C. Legay, N. Morel, S. Simon (1999)
The polymorphism of acetylcholinesterase: post-translational processing, quaternary associations and localization.Chemico-biological interactions, 119-120
J.G. Roddick (1974)
The steroidal glycoalcalooid a-tomatinePhytochemistry, 13
K. Birikh, E. Sklan, S. Shoham, H. Soreq (2002)
Interaction of “readthrough” acetylcholinesterase with RACK1 and PKCβII correlates with intensified fear-induced conflict behaviorProceedings of the National Academy of Sciences of the United States of America, 100
M. Krasowski, D. McGehee, J. Moss (1997)
Natural inhibitors of cholinesterases: implications for adverse drug reactionsCanadian Journal of Anaesthesia, 44
H. Ono, Daio Kozuka, Yukiko Chiba, A. Horigane, K. Isshiki (1997)
Structure and cytotoxicity of dehydrotomatine, a minor component of tomato glycoalkaloidsJournal of Agricultural and Food Chemistry, 45
M. Weill, P. Fort, A. Berthomieu, M. Dubois, N. Pasteur, M. Raymond (2002)
A novel acetylcholinesterase gene in mosquitoes codes for the insecticide target and is non–homologous to the ace gene DrosophilaProceedings of the Royal Society of London. Series B: Biological Sciences, 269
C.B. Hall (1994)
Prospects for a respiratory synctial vaccineScience, 265
J. Taylor, J. O'Brien, M. Yeager (1996)
The cytoplasmic tail of NSP4, the endoplasmic reticulum‐localized non‐structural glycoprotein of rotavirus, contains distinct virus binding and coiled coil domains.The EMBO Journal, 15
Edward Hyde, Wayne Carmichael (1991)
Anatoxin-a(s), a naturally occurring organophosphate, is an irreversible active site-directed inhibitor of acetylcholinesterase (EC 3.1.1.7).Journal of biochemical toxicology, 6 3
A. Tretyn, R.E. Kendrick (1991)
Acetylcholine in plants: presence, metabolism and mechanism of actionBot. Rev., 57
R. Fischer, N. Emans (2004)
Molecular farming of pharmaceutical proteinsTransgenic Research, 9
N. Kozukue, E. Kozukue, Hideyo Yamashita, S. Fujii (1994)
Alpha-tomatine purification and quantification in tomatoes by HPLCJournal of Food Science, 59
Y. Ashani (2000)
Prospective of human butyrylcholinesterase as a detoxifying antidote and potential regulator of controlled‐release drugsDrug Development Research, 50
R. Sandrock, D. DellaPenna, H. Vanetten (1995)
Purification and characterization of beta 2-tomatinase, an enzyme involved in the degradation of alpha-tomatine and isolation of the gene encoding beta 2-tomatinase from Septoria lycopersici.Molecular plant-microbe interactions : MPMI, 8 6
A. Karczmar (1998)
Invited Review Anticholinesterases: dramatic aspects of their use and misuseNeurochemistry International, 32
Anjali Gupta, M. Vijayaraghavan, R. Gupta (1998)
The presence of cholinesterase in marine algaePhytochemistry, 49
D. Glick, M. Shapira, H. Soreq (2002)
Siteselective Neurotoxicity
R. Fluck, M. Jaffe (1974)
Cholinesterases from Plant Tissues: III. Distribution and Subcellular Localization in Phaseolus aureus Roxb.Plant physiology, 53 5
V.V. Roshchina (2001)
Nerotransmitters in Plant Life
H. Soreq, R. Ben-Aziz, C. Prody, S. Seidman, A. Gnatt, L. Neville, J. Lieman-Hurwitz, E. Lev-Lehman, D. Ginzberg, Y. Lipidot-Lifson (1990)
Molecular cloning and construction of the coding region for human acetylcholinesterase reveals a G + C-rich attenuating structure.Proceedings of the National Academy of Sciences of the United States of America, 87 24
A. Martín-Hernández, M. Dufresne, V. Hugouvieux, R. Melton, A. Osbourn (2000)
Effects of targeted replacement of the tomatinase gene on the interaction of Septoria lycopersici with tomato plants.Molecular plant-microbe interactions : MPMI, 13 12
J. Roddick (1989)
The acetylcholinesterase-inhibitory activity of steroidal glycoalkaloids and their aglyconesPhytochemistry, 28
D. Glick, M. Shapira, H. Soreq (2002)
Molecular neurotoxicology implications of acetylcholinesterase inhibition
C. Rick, J. Uhlig, A. Jones (1994)
High alpha-tomatine content in ripe fruit of Andean Lycopersicon esculentum var. cerasiforme: developmental and genetic aspects.Proceedings of the National Academy of Sciences of the United States of America, 91 26
C. Prody, D. Zevin-Sonkin, A. Gnatt, O. Goldberg, H. Soreq (1987)
Isolation and characterization of full-length cDNA clones coding for cholinesterase from fetal human tissues.Proceedings of the National Academy of Sciences of the United States of America, 84 11
G. Ehrlich, D. Ginzberg, Y. Loewenstein, D. Glick, B. Kerem, S. Ben-Ari, H. Zakut, H. Soreq (1994)
Population diversity and distinct haplotype frequencies associated with ACHE and BCHE genes of Israeli Jews from trans-Caucasian Georgia and from Europe.Genomics, 22 2
Y. Momonoki (1997)
Asymmetric Distribution of Acetylcholinesterase in Gravistimulated Maize Seedlings, 114
M. Sternfeld, J. Patrick, H. Soreq (1998)
Position effect variegations and brain-specific silencing in transgenic mice overexpressing human acetylcholinesterase variantsJournal of Physiology-Paris, 92
D. McGehee, M. Krasowski, D. Fung, B. Wilson, G. Gronert, J. Moss (2000)
Cholinesterase Inhibition by Potato Glycoalkaloids Slows Mivacurium MetabolismAnesthesiology, 93
Sun Kim, J. Kwak, J. Kwak, Seul-Ki Jae, Myeon-Hyeon Wang, H. Nam (2001)
Overexpression of the AtGluR2 gene encoding an Arabidopsis homolog of mammalian glutamate receptors impairs calcium utilization and sensitivity to ionic stress in transgenic plants.Plant & cell physiology, 42 1
G. Oldroyd, B. Staskawicz (1998)
Genetically engineered broad-spectrum disease resistance in tomato.Proceedings of the National Academy of Sciences of the United States of America, 95 17
E. Hartmann, R. Gupta (1989)
Second Messengers in Plant Growth and Development
I. Wessler, C. Kirkpatrick, K. Racké (1999)
THE CHOLINERGIC ‘PITFALL’: ACETYLCHOLINE, A UNIVERSAL CELL MOLECULE IN BIOLOGICAL SYSTEMS, INCLUDING HUMANSClinical and Experimental Pharmacology and Physiology, 26
R. Fluck, M. Jaffe (1974)
The distribution of cholinesterases in plant speciesPhytochemistry, 13
Shanti Sharma, S. Sharma, V. Rai (1987)
Tomatine, its effect and interaction with abscisic acid on stomatal opening in Commelina communisPhytochemistry, 26
H. Soreq, S. Seidman (2001)
Acetylcholinesterase — new roles for an old actorNature Reviews Neuroscience, 2
J. Wierenga, R. Hollingworth (1992)
Inhibition of insect acetylcholinesterase by the potato glycoalkaloid alpha-chaconine.Natural toxins, 1 2
Ashu Gupta, R. Gupta (1997)
A survey of plants for presence of cholinesterase activityPhytochemistry, 46
P. Taylor (1996)
Goodman & Gilman's The Pharmacological Basis of Therapeutics
J. Massoulie, A. Anselmet, S. Bon, E. Krejci, C. Legay, N. Morel, S. Simon (1998)
Acetylcholinesterase: C-terminal domains, molecular forms and functional localizationJournal of Physiology-Paris, 92
D. Combes, Y. Fedon, J. Toutant, M. Arpagaus (2001)
Acetylcholinesterase genes in the nematode Caenorhabditis elegans.International review of cytology, 209
S. Madhavan, G. Sarath, Bong-Ho Lee, Randall Pegden (1995)
Guard cell protoplasts contain acetylcholinesterase activityPlant Science, 109
J. Roddick (1996)
Steroidal glycoalkaloids: nature and consequences of bioactivity.Advances in experimental medicine and biology, 404
M. Raves, M. Harel, Y. Pang, I. Silman, A. Kozikowski, J. Sussman (1997)
Structure of acetylcholinesterase complexed with the nootropic alkaloid, (–)-huperzine ANature Structural Biology, 4
Acetylcholinesterase, a major component of the central and peripheral nervous systems, is ubiquitous among multicellular animals, where its main function is to terminate synaptic transmission by hydrolyzing the neurotransmitter, acetylcholine. However, previous reports describe cholinesterase activities in several plant species and we present data for its presence in tomato plants. Ectopic expression of a recombinant form of the human enzyme and the expression pattern of the transgene and the accumulation of its product in transgenic tomato plants are described. Levels of acetylcholinesterase activity in different tissues are closely effected by and can be separated from α-tomatine, an anticholinesterase steroidal glycoalkaloid. The recombinant enzyme can also be separated from the endogenous cholinesterase activity by its subcellular localization and distinct biochemical properties. Our results provide evidence for the co-existence in tomato plants of both acetylcholinesterase activity and a steroidal glycoalkaloid with anticholinesterase activity and suggest spatial mutual exclusivity of these antagonistic activities. Potential functions, including roles in plant-pathogen interactions are discussed.
Plant Molecular Biology – Springer Journals
Published: Dec 30, 2004
Access the full text.
Sign up today, get DeepDyve free for 14 days.