OBES SURG (2017) 27:3133–3141 DOI 10.1007/s11695-017-2754-y ORIGINAL CONTRIBUTIONS Timeline of Intestinal Adaptation After Malabsortive Surgery: Effect of Luminal Nutrients, Biliopancreatic Secretion, and Glutamine Supplementation 1 2 José Manuel Martínez Moreno & Alexander Reyes-Ortiz & 3 1 1 José María Lage Sánchez & Pilar Sánchez-Gallegos & Manuel Garcia-Caballero Published online: 4 June 2017 Springer Science+Business Media New York 2017 Abstract operation (transection) as thenegativecontrol.Wemeasured Background The aim of this study was to study the process of the height and width of intestinal villi, histidine decarboxylase intestinal adaptation in the three limbs of the small intestine after (HDC) activity, and amount of HDC messenger RNA (mRNA) malabsorptive bariatric surgery: the biliopancreatic limb, the (standard diet or a diet supplemented with glutamine). alimentary limb, and the common channel. These limbs are Results An increase in HDC activity and mRNA expression exposed to different stimuli, namely, gastrointestinal transit was observed in the BPBP group. This increase coincided with and nutrients in the alimentary limb, biliopancreatic secretions an increase in the height and width of the intestinal villi. The in the biliopancreatic limb, and a mix of both in the common increase in villus height was observed immediately after surgery channel. We also wished
Obesity Surgery – Springer Journals
Published: Jun 4, 2017
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