Three proposed new bacteriophage genera of staphylococcal phages: “3alikevirus”, “77likevirus” and “Phietalikevirus”

Three proposed new bacteriophage genera of staphylococcal phages: “3alikevirus”,... To date, most members of the Siphoviridae family of bacteriophages remain unclassified, including the 46 staphylococcal phages for which the complete genome sequences have been deposited in public databases. Comparative nucleotide and protein sequence analysis, in addition to available data on phage morphology, allowed us to propose three new phage genera within the family Siphoviridae : “3alikevirus”, “77likevirus” and “Phietalikevirus”, which include related phages infecting Staphylococcus aureus and Staphylococcus epidermidis . However, six phages infecting S. aureus , Staphylococcus pasteuri , Staphylococcus hominis and Staphylococcus capitis strains remain to be classified (orphan phages). Overall, the former phages share morphological features and genome organization. The three groups have conserved domains containing peptidoglycan hydrolytic activities clearly identified as part of tape measure proteins (“3alikevirus” and “77likevirus”) or as individual virion-associated proteins (“Phietalikevirus”). In addition, bacteriophages belonging to the genus “3alikevirus” share closely related DNA-processing and packaging proteins, while bacteriophages included in the genus “Phietalikevirus” encode specific tail proteins for host interaction. These properties are considered distinctive for these genera. Orphan phages seem to have a more divergent organization, but they share some properties with members of these proposed genera. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Three proposed new bacteriophage genera of staphylococcal phages: “3alikevirus”, “77likevirus” and “Phietalikevirus”

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Publisher
Springer Vienna
Copyright
Copyright © 2014 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-013-1833-1
Publisher site
See Article on Publisher Site

Abstract

To date, most members of the Siphoviridae family of bacteriophages remain unclassified, including the 46 staphylococcal phages for which the complete genome sequences have been deposited in public databases. Comparative nucleotide and protein sequence analysis, in addition to available data on phage morphology, allowed us to propose three new phage genera within the family Siphoviridae : “3alikevirus”, “77likevirus” and “Phietalikevirus”, which include related phages infecting Staphylococcus aureus and Staphylococcus epidermidis . However, six phages infecting S. aureus , Staphylococcus pasteuri , Staphylococcus hominis and Staphylococcus capitis strains remain to be classified (orphan phages). Overall, the former phages share morphological features and genome organization. The three groups have conserved domains containing peptidoglycan hydrolytic activities clearly identified as part of tape measure proteins (“3alikevirus” and “77likevirus”) or as individual virion-associated proteins (“Phietalikevirus”). In addition, bacteriophages belonging to the genus “3alikevirus” share closely related DNA-processing and packaging proteins, while bacteriophages included in the genus “Phietalikevirus” encode specific tail proteins for host interaction. These properties are considered distinctive for these genera. Orphan phages seem to have a more divergent organization, but they share some properties with members of these proposed genera.

Journal

Archives of VirologySpringer Journals

Published: Feb 1, 2014

References

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