Thiazolyl-pyrazole-biscoumarin synthesis and evaluation of their antibacterial and antioxidant activities

Thiazolyl-pyrazole-biscoumarin synthesis and evaluation of their antibacterial and antioxidant... + 1 R 1 6 + + Ar 2 2 Ar' 2 2 2 2 Electronic supplementary material The online version of this article (doi:10.1007/s11164-016-2644-2) contains supplementary material, which is available to authorized users. & Nosrat O. Mahmoodi mahmoodi@guilan.ac.ir; nosmahmoodi@gmail.com Department of Organic Chemistry, Faculty of Sciences, University of Guilan, PO Box 41335-1914, Rasht, Iran Faculty of Science, School of Chemistry, University of Tehran, Tehran, Iran %U 1+ 662 N. O. Mahmoodi, S. Ghodsi Keywords Thiazolo-pyrazolium  Coumarin  One-pot reaction  Antibacterial Antioxidant Introduction In recent years, many studies, either by our research group or others, were carried out on heterocyclic systems bearing thiazole and pyrazoline groups as pharma- cophores. Compounds possessing pyrazoles and pyrazolines are an interesting class of heterocycles because of their synthetic flexibility and useful biological activities [1], serving as antimicrobials [2, 3], antivirals [4], anti-inflammatories [5, 6], antidepressants [7], antituberculars [8], antiamoebics [9], and analgesics [10]. Similarly, the thiazole moiety is a prevalent scaffold in a number of naturally occurring and synthetic molecules with remarkable medicinal value due to their potential chemotherapeutic [11], fungicidal [12], antiviral [13], antibacterial [14], anti-HIV [15], hypnotic [16], pesticidal [17], anticonvulsant, anti-inflammatory [18] enzyme inhibition [19] and antitumour activities http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Thiazolyl-pyrazole-biscoumarin synthesis and evaluation of their antibacterial and antioxidant activities

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Publisher
Springer Netherlands
Copyright
Copyright © 2016 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-016-2644-2
Publisher site
See Article on Publisher Site

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