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Thiamazole

Thiamazole Reactions 1704, p359 - 2 Jun 2018 Agranulocytosis: case report A 61-year-old woman developed agranulocytosis during treatment with thiamazole for hyperthyroidism [route and dosage not stated]. The woman admitted to the emergency department with the complaints of fever, chills, cough and general weaknesses. These symptoms were started a day after her discharge from a hospital. During her previous hospitalisation, she received treatment for gastric pain and neutropenia, induced by thiamazole. She had a history of hyperthyroidism for 21 years, and 6 months prior to the previous hospitalisation, she started receiving thiamazole. At the time of admission to current hospital (current presentation), she was febrile with a temperature of 38.8 °C and her RR was 22 /min. Physical examination showed atonic bilateral equal air entry. Her chest X-ray revealed a multifocal abscessing pneumonia. A CT confirmed multifocal abscesses in lungs. Her lab investigation showed a haemoglobin of 12.5 gm/dL, WBC count of 9 9 8.8 × 10 /L, neutrophil 5.59×10 /L and platelets count of 197×10 /L. Arterial blood gas analysis showed a pH of 7.30 and PaO2 of 60mm Hg, PCO2 of 46mm Hg and SaO2 of 90% [duration of treatment to reaction onset not clearly stated]. Initially, the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Thiamazole

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018

Thiamazole

Abstract

Reactions 1704, p359 - 2 Jun 2018 Agranulocytosis: case report A 61-year-old woman developed agranulocytosis during treatment with thiamazole for hyperthyroidism [route and dosage not stated]. The woman admitted to the emergency department with the complaints of fever, chills, cough and general weaknesses. These symptoms were started a day after her discharge from a hospital. During her previous hospitalisation, she received treatment for gastric pain and neutropenia, induced by thiamazole....
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References (1)

Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
DOI
10.1007/s40278-018-47002-8
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p359 - 2 Jun 2018 Agranulocytosis: case report A 61-year-old woman developed agranulocytosis during treatment with thiamazole for hyperthyroidism [route and dosage not stated]. The woman admitted to the emergency department with the complaints of fever, chills, cough and general weaknesses. These symptoms were started a day after her discharge from a hospital. During her previous hospitalisation, she received treatment for gastric pain and neutropenia, induced by thiamazole. She had a history of hyperthyroidism for 21 years, and 6 months prior to the previous hospitalisation, she started receiving thiamazole. At the time of admission to current hospital (current presentation), she was febrile with a temperature of 38.8 °C and her RR was 22 /min. Physical examination showed atonic bilateral equal air entry. Her chest X-ray revealed a multifocal abscessing pneumonia. A CT confirmed multifocal abscesses in lungs. Her lab investigation showed a haemoglobin of 12.5 gm/dL, WBC count of 9 9 8.8 × 10 /L, neutrophil 5.59×10 /L and platelets count of 197×10 /L. Arterial blood gas analysis showed a pH of 7.30 and PaO2 of 60mm Hg, PCO2 of 46mm Hg and SaO2 of 90% [duration of treatment to reaction onset not clearly stated]. Initially, the

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

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