1070-4272/04/7707-1079C2004 MAIK [Nauka/Interperiodica]
Russian Journal of Applied Chemistry, Vol. 77, No. 7, 2004, pp. 1079!1082. Translated from Zhurnal Prikladnoi Khimii, Vol. 77, No. 7,
2004, pp. 1094!1097.
Original Russian Text Copyright + 2004 by Kasenova, Tukhmetova, Abil’daeva, Adekenov, Kasenov, Dzhalmakhanbetova.
OF SYSTEMS AND PROCESSES
Thermodynamic Properties of Dimethylaminoarglabin Methyl
NI and Its Analogs
Sh. B. Kasenova, Zh. K. Tukhmetova, A. Zh. Abil’daeva, S. M. Adekenov,
B. K. Kasenov, and R. I. Dzhalmakhanbetova
Institute of Phytochemistry, Ministry of Education and Science of the Kazakhstan Republic,
Received February 11, 2004
Abstract-The heat of solution of dimethylaminoarglabin methyl iodide C
NI at dilutions (mole of
salt/mole of water) of 1 : 75000, 1 : 100 000, and 1 : 150000 was determined by isothermal calorimetry.
The data obtained were used to calculate the standard heat of solution of the compound in an infinitely dilute
(standard) aqueous solution. The heats of combustion, melting, and formation of C
NI and 33 its
analogs were estimated by approximate methods of chemical thermodynamics.
Calorimetric methods, which are the primary source
of information in physical chemistry of solutions, are
the most commonly used in biochemical thermo-
dynamics . A study of thermochemical and ther-
modynamic properties of terpenoids is of certain
theoretical and practical significance for their con-
trolled synthesis. In this respect, natural sesquiterpene
lactones, most of which possess a wide spectrum of
biological activity, are of interest . Various phar-
maceuticals based on sesquiterpene lactones have
been and are being developed. For example, original
antitumor preparation Arglabin based on sesquiter-
pene lactone derived from Artemisia glabella Kar.
et Kir., growing solely in Central Kazakhstan, was
developed and applied in medicine . The Arglabin
drug was registered in the Kazakhstan Republic,
and its registration in the Russian Federation is in
Thermochemical and thermodynamic properties of
sesquiterpene lactones of the general formula
(including Arglabin) and its derivatives
have been studied previously .
In this work, we studied experimentally the en-
thalpy of solution of dimethylaminoarglabin methyl
NI in water.
The structural formula
The compound of the pharmacopoeia purity was prepared at
the Laboratory of Terpenoid Chemistry of the Institute of
of dimethylaminoarglabin methyl iodide is presented
The enthalpy of solution of the compound was
studied on a DAK-1-1A automated differential calor-
imeter at 25oC at dilutions (mole of substance/mole of
water) of 1 : 75000, 1 : 100000, and 1 : 150 000.
The heat of solution was determined in the automatic
heat compensation mode. The thermal effects were
recorded with a KSP-4 self-recorder and IP-4 preci-
sion integrator. The time of the preliminary thermo-
stating of the substance was 2 h. The integrator drift
did not exceed three units of the last digit in 100 s.
Prior to the experiment, the instrument was calibrated
by Joulean heat. To do this, a calibrated voltage was
supplied to a built-in heater of the instrument, and the
released power was measured. The calibration of the
instrument was checked by measuring the heat of
solution of triply recrystallized potassium chloride
at dilutions (mole of salt/mole of water) of 1 : 1600,
1 : 2400, and 1 : 3200. The average heat of the KCl
solution in water (17860+283 J mol
) agrees well
(to within 1.632.0%) with the known values of
17577+34  and 17489+371 J mol