Russian Journal of Applied Chemistry, 2012, Vol. 85, No. 12, pp. 1914−1918.
Pleiades Publishing, Ltd., 2012.
Original Russian Text © Sh.B. Kasenova, A.Zh. Abil’daeva, B.K. Kasenov, Zh.S. Nurmaganbetov, S.M. Adekenov, 2012, published in Zhurnal Prikladnoi
Khimii, 2012, Vol. 85, No. 12, pp. 2029−2033.
OF SYSTEMS AND PROCESSES
Thermodynamic Properties of Biologically Active Substances:
Sh. B. Kasenova
, A. Zh. Abil’daeva
, B. K. Kasenov
, Zh. S. Nurmaganbetov
and S. M. Adekenov
Abishev Chemical-Metallurgical Institute, Karaganda, Kazakhstan
Fitokhimiya International Research and Production Holding, Joint-Stock Company, Karaganda, Kazakhstan
Received March 30, 2012
Abstract—The enthalpies of solution of 3-acetyl-9-methoxy-2-phenyl-11H-indolizino[8,7-b]indole and 8-acetyl-
harmine in dimethyl sulfoxide were measured by isothermal calorimetry at solute : solvent molar ratios of 1 : 9000,
1 : 18000, and 1 : 36000. From the data obtained, the standard enthalpies of solution of the compounds in dimethyl
sulfoxide at inﬁ nite dilution were calculated. The heat capacities of 8-acetylharmine were determined by dynamic
calorimetry in the interval 298.15–673 K, and the С
= f(T) equations were obtained. The standard enthalpies of
combustion of the compounds were estimated by approximate methods, and their heats of melting were calculated.
From the data obtained, using Hess cycle, the standard enthalpies of formation of the compounds were calculated.
It is known that the properties of biologically active
substances are closely associated with their structure.
Therefore, it is important to elucidate the relationships
between the structure, physicochemical properties, and
The development of efﬁ cient technologies for produc-
tion of any chemical substances, in particular, of drugs,
requires information on thermochemical and thermody-
namic characteristics of the processes under consideration
and of substances participating in them. These data are
necessary for taking into account the power consumption
in all the steps, for determining the process complete-
ness, and for revealing possible competing pathways
of chemical transformations. Such information is often
lacking, especially for structurally complex substances
of vegetable origin.
The most widely used methods in biochemical ther-
modynamics are calorimetric methods. Some of them
are the main source of thermodynamic information on
physical chemistry of solutions.
The use of calorimetry in biological research led to
signiﬁ cant progress in studying interactions both be-
tween low-molecular-weight substances and between
Calorimetric methods are also of particular interest
for standardization of drugs .
(I) and 8-acetylharmine
(II) were synthesized at the Laboratory
of Alkaloids, Fitokhimiya International Research and
Production Holding, and were of pharmacopoeial level
of purity :